July 201729
Low-dose finasteride and dutasteride in men was found to lower PSA about 28% on average, though PSA stayed stable or rose in 21%. A review concluded experimental androgenetic alopecia treatments remain limited in evidence, with PRP, prostaglandin analogs, cell therapies and improved topicals the likeliest near-term directions. Oral finasteride in transgender men improved Norwood-Hamilton stage by one grade, with no sexual adverse effects observed, though the series covered only ten patients over about 16 months. A systematic review found PRP scalp injections increased hair density by roughly 19–31%, with effects fading without maintenance. A review of common hair loss myths found little evidence for most, advising proven treatments over supplements and natural remedies.
- Change in Prostate Specific Antigen Concentration in Men with Prostate Specific Antigen Less than 2.5 ng/ml Taking Low Dose Finasteride or Dutasteride for Male Androgenetic Alopecia In 1,379 men taking finasteride or dutasteride for hair loss, PSA fell about 28% on average, but stayed stable or rose in 21%, mainly men with very low baseline PSA.
- Experimental and early investigational drugs for androgenetic alopecia A review concludes experimental AGA treatments remain limited in evidence, with PRP, prostaglandin analogs, cell therapies and improved topicals the likely near-term directions.
- Therapeutic experience with oral finasteride for androgenetic alopecia in female-to-male transgender patients In 10 transgender men with pattern hair loss, 1 mg daily finasteride improved Norwood-Hamilton stage by one grade by about 5.5 months, with no sexual adverse effects observed over 16 months follow-up.
- Injections of platelet-rich plasma for androgenic alopecia: A systematic review A review of 14 studies found PRP scalp injections increased hair density by roughly 19-31% and thickened hair in androgenetic alopecia, with effects peaking after 3-5 sessions and fading without maintenance.
- Hair Loss Myths. A review of 12 common hair loss myths found little evidence for most, advising proven treatments over supplements and natural remedies.
- Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling In mice, topical vitamin E tocotrienol accelerated anagen hair cycling via an epidermal E-cadherin/β-catenin pathway, even in diabetic mice resistant to hair cycling.
- Promotion of hair growth by newly synthesized ceramide mimetic compound A new pseudoceramide (BOI) promoted hair growth in cultured human follicles and mice by boosting sphingolipid synthesis in dermal papilla cells.
- Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis A meta-analysis of 2007 breast cancer patients found CDK4/6 inhibitors more than doubled the risk of alopecia (RR 2.14) and raised fatigue and stomatitis risks.
- Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice. Injecting cultured adult human dermal papilla and epithelial cells together induced new hair growth in nude mice, while single cell types did not.
- Hair Diameter Variation in Different Vertical Regions of the Occipital Safe Donor Area In 27 patients, hair diameter in the occipital donor zone decreased from top to bottom, suggesting upper zones suit scalp transplants and lower zones finer work like eyebrows.
- Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness A first patient series of stem cell-enriched autologous fat grafting injected into the scalp found the approach safe and suggested promise for early genetic hair loss.
- The patch assay reconstitutes mature hair follicles by culture-expanded human cells A patch assay injecting culture-expanded human dermal cells with keratinocytes into mice efficiently reconstituted mature hair follicles, useful for testing cell trichogenicity.
- Tissue and Circulating MicroRNA Co-expression Analysis Shows Potential Involvement of miRNAs in the Pathobiology of Frontal Fibrosing Alopecia A study mapping microRNA co-expression in tissue and blood from frontal fibrosing alopecia patients.
- Hairless controls hair fate decision via Wnt/β–catenin signaling In mutant mice, loss of the hairless protein reduces Wnt/β-catenin signaling, diverting follicle progenitor cells away from the hair fate.
- Brazilian Experience of the Treatment of Alopecia Universalis with the Novel Antirheumatic Therapy Tofacitinib: A Case Series Four Brazilian patients with alopecia universalis, two etanercept-induced, were treated with tofacitinib; authors say it should be considered for severe alopecia areata pending trials.
- A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents A review gives a diagnostic algorithm and management overview for hair loss in children and adolescents, where causes differ from adults.
- Thermal imaging and dermoscopy for detecting inflammation in frontal fibrosing alopecia In 22 women with frontal fibrosing alopecia, combining thermal imaging with dermoscopy best identified active inflammation for biopsy.
- Platelet-rich plasma—an ‘Elixir’ for treatment of alopecia: personal experience on 117 patients with review of literature A 117-patient experience paper proposes PRP acts on a 'golden anchorage' hair model and presents it as a valuable adjuvant for non-scarring alopecias.
- Alopecia Areata: a Comprehensive Review of Pathogenesis and Management A review of alopecia areata pathogenesis notes few treatments are well proven in trials, with corticosteroids and topical immunotherapy mainstays and JAK inhibitors under study.
- β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model In cultured human hair follicles, oleanolic acid elongated hair shafts and boosted matrix cell proliferation via Wnt/β-catenin signaling.
- Frontal fibrosing alopecia among men: A clinicopathologic study of 7 cases A 7-case series shows frontal fibrosing alopecia in men involves frontal scalp, sideburns and temporal scalp, paralleling the disease in women.
- Hierarchical patterning modes orchestrate hair follicle morphogenesis In developing skin, an epidermal FGF/WNT/BMP prepattern directs mesenchymal cell clustering in hair follicle formation, with backup self-organisation capacity.
- Topically used herbal products for the treatment of hair loss: preclinical and clinical studies A review summarizes preclinical and clinical evidence on topically used herbal products for hair loss, their mechanisms and possible adverse effects.
- Oxidative stress management in the hair follicle: Could targeting NRF2 counter age‐related hair disorders and beyond? A review proposes activating the NRF2 antioxidant pathway could counter redox-driven hair disorders including AGA, greying and chemotherapy-induced hair loss.
- Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia A novel vitamin D receptor mutation caused hereditary rickets with alopecia by abolishing receptor function in a child.
- Platelet-Rich Plasma in the Treatment of Hair Disorders a review of platelet-rich plasma in treating hair disorders.
- Efficacy of topical caffeine in male androgenetic alopecia a study of topical caffeine efficacy in male androgenetic alopecia.
- Effect of laser diode light irradiation on growth capability of human hair follicle dermal papilla cells In cultured human dermal papilla cells, 808 nm laser light increased proliferation and Sox2/Fgf7 gene expression at low doses.
- Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells In mice, quiescent hair follicle stem cells keep hyperdynamic chromatin linked to high cell-fate plasticity.