April 201727
A meta-analysis of randomized trials found minoxidil, finasteride, and low-level laser therapy beat placebo for androgenetic alopecia. In 133 patients followed three years, Biofibre artificial hair implants lost under 10% of fibers per year in most cases, with 96% satisfaction. Donor hair in Asian subjects thinned from occipital to temporal zones, guiding graft selection for hairlines versus denser coverage. In a randomized trial in women, zinc plus calcium pantothenate modestly increased hair density, while minoxidil raised density and pantothenate raised thickness most.
- The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis A meta-analysis of randomized trials confirms minoxidil, finasteride, and low-level laser therapy all beat placebo for androgenetic alopecia.
- Hair diameter evaluation in different regions of the safe donor area in Asian populations In 38 Asian subjects, donor hair thinned from occipital to temporal zones, guiding graft selection for hairlines versus denser coverage.
- Comparing the effects of zinc sulfate, calcium pantothenate, their combination and minoxidil solution regimens on controlling hair loss in women: A randomized controlled trial In a 73-woman trial, zinc plus calcium pantothenate modestly increased hair density, while minoxidil raised density and pantothenate raised thickness most.
- The evolution of artificial hair implantation. In 133 androgenetic alopecia patients followed 3 years, Biofibre artificial hair implants lost under 10% of fibers per year in most cases, with 96% patient satisfaction.
- Genetics and other factors in the aetiology of female pattern hair loss A review finds female pattern hair loss genetics differ substantially from men's, with no clear susceptibility gene identified.
- Serum vitamin D level is related to disease severity in pediatric alopecia areata In 20 children with alopecia areata, lower vitamin D levels correlated with greater disease severity, patch count and duration, though levels did not differ from controls.
- Frontal fibrosing alopecia: clinical and prognostic classification In 242 women, frontal fibrosing alopecia fell into three prognostic patterns, and dutasteride plus topical steroids stabilized 37% of treated patients.
- CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homoeostasis and induces autoimmune-like alopecia Mice lacking CD80/CD86 developed near-universal autoimmune-like hair loss by 40 weeks, linked to depleted regulatory T cells, offering a new alopecia areata model.
- Higher plasma leptin is associated with higher risk of androgenetic alopecia in men In 48 men, higher plasma leptin was associated with roughly triple the odds of androgenetic alopecia.
- As a carrier–transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells In mice, platelet-rich plasma gel boosted dermal papilla cell growth and supported formation of new hair follicles.
- A new path in defining light parameters for hair growth: Discovery and modulation of photoreceptors in human hair follicle In human hair follicles grown in the lab, low-dose 453 nm blue light prolonged the growth phase, possibly via the light receptor opsin 3, while red light did not.
- Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies A review highlights hair follicle dermal stem cells as a renewable progenitor pool for future hair restoration therapies.
- Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles The authors describe their micro-dissection and 3D culture methods for growing human dermal papilla cells.
- Genomewide differential expression profiling of long non-coding RNAs in androgenetic alopecia in a Chinese male population Over two thousand long non-coding RNAs were differentially expressed in balding versus adjacent scalp, nominating candidate treatment targets.
- Identification of hair shaft progenitors that create a niche for hair pigmentation In mice, KROX20-expressing matrix progenitor cells are required for hair growth and create an SCF-dependent niche that maintains hair pigmentation.
- Sex Hormones and Hair Loss in Men From the General Population of Northeastern Germany. a population study examines sex hormones and hair loss in men in northeastern Germany.
- Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways Bald scalp biopsies showed overexpressed inflammatory and mast-cell genes and suppressed Wnt and vitamin D pathway activity.
- Bioactives in Chinese Proprietary Medicine Modulates 5α-Reductase Activity and Gene Expression Associated with Androgenetic Alopecia In cultured dermal papilla cells, ferulic acid and emodin from a Chinese herbal capsule promoted proliferation and modulated alopecia-related genes.
- Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal In mice, platelet-derived growth factor signaling proved essential to maintain hair follicle dermal stem cells and their regenerative capacity.
- The ovariectomized mouse simulates the pathophysiology of postmenopausal female pattern hair loss ovariectomized mice are proposed as a model of postmenopausal female pattern hair loss.
- Review of treatment for alopecia totalis and alopecia universalis A review of alopecia totalis and universalis treatments finds none fully effective, with contact immunotherapy and steroids most promising.
- Th1/Th2 PB balance and CD200 expression of patients with active severe alopecia areata Patients with active severe alopecia areata had lower CD200 expression on blood lymphocytes and hair follicles, alongside a shifted Th1/Th2 balance.
- Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix Mapping of cell-cycle proteins in the human hair matrix shows how matrix keratinocytes stop dividing and differentiate during hair shaft formation.
- Update on Frontal Fibrosing Alopecia A review of frontal fibrosing alopecia notes no clinical trials exist, with best observational results for 5-alpha-reductase inhibitors and intralesional corticosteroids.
- A mixed methods survey of social anxiety, anxiety, depression and wig use in alopecia In a survey of 338 people with alopecia, wigs boosted social confidence but fear of them being noticed was linked to higher anxiety and depression.
- Advances in Aesthetic Therapies: Plasma-Rich Protein Procedure for the Treatment of Alopecia An overview describes platelet-rich plasma as a growing nonsurgical, out-of-pocket option for hair loss treatment.
- DERMAL ADIPOSE TISSUE IN HAIR FOLLICLE CYCLING: POSSIBLE APPLICATIONS IN ALOPECIA? A review links dermal fat tissue to hair follicle cycling and proposes adipocyte changes as a step in androgenetic alopecia miniaturization.