August 201712
In a trial for pattern hair loss, PRP with microneedling increased vellus and total hairs with thicker shafts. A meta-analysis found young men with early-onset pattern hair loss showed slightly worse glycolipid profiles and PCOS-like hormonal patterns. A lab study found newborn skin organoid self-organization revealed molecular switches restoring hair-forming ability in adult cells. In mice, lactate production by follicle stem cells was required for activation and topically inducible. In a safety analysis, bupropion among antidepressant users carried the highest hair loss risk while paroxetine and fluoxetine carried the lowest.
- Original article: Platelet-rich plasma with microneedling in androgenetic alopecia along with dermoscopic pre- and post-treatment evaluation In a trial of PRP injections with microneedling for pattern hair loss, patients had more vellus and total hairs, thicker shafts, and over 75% satisfaction after 3 sessions.
- Lactate dehydrogenase activity drives hair follicle stem cell activation In mice, lactate production by hair follicle stem cells is required for their activation, and small molecules boosting lactate topically induced the hair cycle.
- Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells A lab study of newborn skin organoid self-organization identified molecular switches that could restore hair-forming ability in adult skin cells.
- Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A meta-analysis A meta-analysis found young men with early-onset pattern hair loss have slightly worse glycolipid profiles and a PCOS-like hormonal pattern, suggesting metabolic monitoring from the second decade.
- Risk of hair loss with different antidepressants A US claims cohort of over one million antidepressant users found bupropion carried the highest hair loss risk and paroxetine and fluoxetine the lowest.
- Conventional and novel stem cell based therapies for androgenic alopecia A review surveys current and emerging stem cell–based therapies for pattern hair loss, noting mechanisms remain under research.
- Digit ratio 2D:4D is a possible indicator for androgenetic alopecia in males Men with pattern hair loss had lower left-hand 2D:4D digit ratios than controls, but the ratio did not correlate with severity or onset age.
- UVA-1 in the treatment of alopecia areata A study examined UVA-1 phototherapy as a treatment for alopecia areata, an autoimmune form of hair loss.
- Evaluation of the Relationship between Alopecia Areata and Viral Antigen Exposure A database analysis found increased alopecia areata frequency after hepatitis B surface antigen exposure and interferon-beta treatment, with shared epitopes identified.
- Topical cetirizine 1% for treatment of androgenetic alopecia Topical cetirizine 1% for treatment of androgenetic alopecia.
- Increased expression of PD‐L1 and PD‐L2 in dermal fibroblasts from alopecia areata mice In alopecia areata mice, activated T cells up-regulated PD-L1 and PD-L2 in dermal fibroblasts, yet these molecules did not restrain the immune attack.
- Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice In mice, antibiotic-driven overgrowth of Lactobacillus murinus depleted gut biotin and caused hair loss, reversible with biotin supplementation.