March 201734
A 650 nm low-level laser cap was found to increase hair counts 51% over sham in women with androgenetic alopecia. 15% topical minoxidil after 5% failure produced regrowth in 60% of women. A dutasteride update concluded dutasteride outperforms finasteride in trials and meta-analyses, with comparable adverse effects. A PRP meta-analysis found injections increased hair number and thickness in androgenetic alopecia. A genetics meta-analysis identified 63 loci explaining 39% of male-pattern baldness variance. A PRP systematic review found evidence for non-scarring hair loss low quality and contradictory. An AGA review highlighted AR/EDA2R and chromosome 20p11 as major risk loci. Men with androgenetic alopecia showed lower plasma antioxidant activity and higher oxidative stress than controls.
- Novel Approach to Treating Androgenetic Alopecia in Females With Photobiomodulation (Low-Level Laser Therapy) In a multicenter randomized trial, a 650 nm low-level laser cap increased hair counts 51% over sham in women with androgenetic alopecia.
- Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil. In women who failed 5% minoxidil, a 15% topical solution produced significant regrowth in 60% over 12 weeks without adverse events.
- Dutasteride in Androgenetic Alopecia: An Update A review concludes dutasteride outperforms finasteride for androgenetic alopecia in trials and meta-analyses, with comparable adverse effects.
- Platelet-rich plasma for androgenetic alopecia: Does it work? Evidence from meta analysis A meta-analysis of six small studies found PRP injections significantly increased hair number and thickness in androgenetic alopecia, but results need larger trials.
- Androgenetic alopecia: a review A review summarizes AGA pathophysiology, highlighting AR/EDA2R and chromosome 20p11 as major genetic risk loci in this polygenic condition.
- Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF In mice, wound macrophages activate hair follicle stem cells and new follicle formation through dose-dependent TNF–AKT/β-catenin signalling.
- Oxidative stress in androgenetic alopecia. Men with androgenetic alopecia showed lower plasma antioxidant activity and higher markers of oxidative stress than controls.
- Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood Permanent alopecia occurred in 15.6% of childhood stem-cell transplant survivors, mainly linked to busulphan conditioning and graft-versus-host disease.
- Platelet rich plasma for treatment of non-scarring hair loss: systematic review of literature A systematic review found PRP evidence for non-scarring hair loss low quality and contradictory, with only two randomized trials available.
- Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness A meta-analysis of over 10,000 male-pattern baldness cases identified 63 associated loci explaining ~39% of variance, implicating FGF5 and melatonin pathways.
- Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia A review finds bimatoprost useful for eyelash and eyebrow hypotrichosis of various causes, with potential future approval for scalp hair loss.
- Retrospective Assessment of Follicular Unit Density in Asian Men With Androgenetic Alopecia Asian men with androgenetic alopecia averaged 61–64 follicular units per cm² in donor areas, with slight regional variations.
- Understanding patient and physician perceptions of male androgenetic alopecia treatments in Asia-Pacific and Latin America A five-country survey found only 37.6% of male AGA patients satisfied with treatments, with 5-alpha-reductase inhibitors rated highest at 53.9%.
- Treatment of Alopecia Areata With Tofacitinib A Cleveland Clinic records review examines oral tofacitinib treatment of alopecia areata patients.
- In vitro skin models to study epithelial regeneration from the hair follicle In vitro skin models showed intact pilosebaceous units, but not truncated follicles, regenerated multilayered epidermis in de-epidermalized dermis.
- Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin In neonatal mice, hair follicle development and commensal microbes jointly recruit regulatory T cells into skin via Ccl20-Ccr6.
- Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire Microscopy of growing hair follicles mapped mitochondrial activity and reactive oxygen species into a circumferential 'ring of fire'.
- SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction In a mouse graft model, SOCS3 treatment prevented alopecia areata by suppressing CD8+ T-cell activity and IFN-gamma production.
- Cutaneous applied nano-ZnO reduce the ability of hair follicle stem cells to differentiate In newborn mice, topically applied nano-zinc oxide accumulated in hair follicles, inducing stem cell apoptosis and reducing their differentiation capacity.
- Two cases of alopecia areata treated with ruxolitinib: a discussion of ideal dosing and laboratory monitoring Two women with alopecia areata/universalis had near-complete sustained regrowth on oral ruxolitinib for over a year without complications.
- Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation In cultured human dermal papilla cells, sinapic acid boosted proliferation and growth-factor expression via Akt/β-catenin signaling.
- Experience with oral tofacitinib in 8 adolescent patients with alopecia universalis experience with oral tofacitinib in eight adolescent patients with alopecia universalis.
- Comorbidities in patients with alopecia areata comorbidities in patients with alopecia areata.
- Permanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patients Ten breast cancer patients developed permanent alopecia after taxane chemotherapy and hormonal therapy, showing three clinical patterns.
- Variation in male sex hormone levels among the pattern subtypes of hair loss in patients with androgenetic alopecia Male sex hormone levels were compared across pattern subtypes of androgenetic alopecia.
- Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles In outer root sheath cells, double-stranded RNA triggered NLRP3 inflammasome activation and IL-1β release, implicating them in alopecia areata.
- Infundibular protein and RNA microarray analyses from affected and clinically non-affected scalp in male androgenetic alopecia patients Non-invasive sampling in six men with AGA found mild inflammatory markers and altered gene expression only in affected scalp areas.
- Topical Minoxidil For the Treatment of Alopecia Areata. In 10 alopecia areata patients, 1% topical minoxidil produced no significant hair growth after three months.
- New Treatments for Hair Loss A review lists emerging hair-loss treatments including new minoxidil formulations, prostaglandin agents, laser therapy, JAK inhibitors and robotic transplant devices.
- Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier In SCD1-deficient mice, an artificial skin lipid barrier restored Wnt3a signaling and reactivated the hair growth cycle, reversing alopecia.
- A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia Genome-wide comparison of bald and haired scalp implicated apoptosis, WNT signalling and neural pathways, nominating five candidate therapeutic targets.
- Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways identification of differentially expressed miRNAs in alopecia areata targeting immune-regulatory pathways.
- Various Types of Minor Trauma to Hair Follicles During Follicular Unit Extraction for Hair Transplantation Examination of FUE grafts revealed transection around 6–7% plus frequent minor paring and bulb injuries, relevant to surgical technique choices.
- Pretrimmed versus Direct Nonshaven Follicular Unit Extraction In 42 transplant patients, direct nonshaven FUE was faster while pretrimmed FUE yielded slightly more hairs per graft; both worked.