January 201550
Platelet-rich plasma injections in men were found to improve hair count, thickness and root strength. Topical minoxidil plus finasteride replacing oral finasteride was reported to maintain hair density in 84% of men. 5% minoxidil foam in a placebo-controlled trial improved hair density and width frontotemporally and at the vertex. Omega 3&6 with antioxidants in women improved hair density and reduced telogen hair percentage. Topical rice bran CO2 extract in men was found to increase hair density and diameter. Early-onset pattern hair loss in young men was associated with nearly triple the metabolic syndrome rate, though a separate case-control comparison found no significant difference. Bimatoprost for scalp alopecia areata regrew patches faster than mometasone, with fewer side effects.
- Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride In 50 men with pattern hair loss, replacing oral finasteride with topical minoxidil plus 0.1% finasteride maintained hair density in 84% over continued treatment, avoiding indefinite oral finasteride.
- A Single-Centre, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men In a 70-man placebo-controlled trial, 5% minoxidil foam improved hair density and width in the frontotemporal hairline as well as the vertex over 24 weeks.
- Efficacy of platelet-rich plasma in treatment of androgenic alopecia In 10 men with pattern hair loss, PRP injections over 3 months improved hair count, thickness and root strength with no major adverse effects.
- Chitosan nanoparticles for targeting and sustaining minoxidil sulphate delivery to hair follicles Chitosan nanoparticles doubled minoxidil delivery into hair follicles in lab skin tests and sustained its release five-fold.
- The ginsenosides of Panax ginseng promote hair growth via similar mechanism of minoxidil ginseng compounds (ginsenosides) reportedly promote hair growth through a mechanism similar to minoxidil.
- Effect of a nutritional supplement on hair loss in women In a 120-woman randomized trial, 6 months of omega 3&6 and antioxidant supplements improved hair density and reduced telogen hair percentage versus control.
- The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia A review: blocking the parathyroid hormone receptor stimulated hair growth in mice, including after cyclophosphamide, suggesting a target for chemotherapy-induced alopecia.
- Bimatoprost versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study In a 30-patient pilot trial, bimatoprost solution regrew patchy alopecia areata faster and with fewer side effects than mometasone cream.
- A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of an Extra-Strength Marine Protein Supplement to Promote Hair Growth and Decrease Shedding in Women with Self-Perceived Thinning Hair In a 60-woman placebo-controlled trial, 90 days of marine protein supplement significantly increased terminal hairs and reduced shedding, with no adverse events.
- Scalp Dermoscopy or Trichoscopy A review describes trichoscopy as a quick noninvasive technique that enhances diagnosis of androgenetic alopecia and other hair disorders, reducing biopsy need.
- Female Pattern Hair Loss A review concludes early treatment and combining modalities appear more effective than monotherapy for female pattern hair loss.
- The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia In 226 chemotherapy patients, sensor-controlled scalp cooling prevented visible hair loss in 65%; success depended on regimen, comorbidities, medications, smoking and hair density.
- Trichoscopic Findings of Hair Loss in Koreans In 327 Korean hair-loss patients, trichoscopy distinguished alopecia types; features matched Caucasians except pigment-pattern frequencies differed.
- Is There Really Relationship between Androgenetic Alopecia and Metabolic Syndrome? In 74 men with pattern hair loss versus 42 controls, metabolic syndrome rates did not differ significantly, contradicting most earlier studies.
- Safety and Efficacy of Rice Bran Supercritical CO<sub>2</sub> Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial In a 50-patient 16-week RCT, topical rice bran CO2 extract significantly increased hair density and diameter in men with androgenic alopecia, with no adverse reactions.
- Is early onset androgenic alopecia a marker of metabolic syndrome and carotid artery atherosclerosis in young Indian male patients? Young men with early-onset pattern hair loss had metabolic syndrome nearly three times as often as controls (22% vs 8%), suggesting screening may be warranted.
- A marine protein-based dietary supplement for subclinical hair thinning/loss: Results of a multisite, double-blind, placebo-controlled clinical trial In a 96-woman placebo-controlled trial, a marine protein supplement reduced shedding and increased vellus-like hair diameter over 6 months.
- The genetics of alopecia areata: New approaches, new findings, new treatments A review summarising genetic research on alopecia areata and possible new therapeutic strategies arising from it.
- <i>In vivo</i>hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice In nude mice, topical Chrysanthemum extract outperformed 2% minoxidil in follicle count by repairing a follicular keratinocyte defect.
- mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration In mice, mTOR signaling activates hair follicle stem cells by countering BMP-mediated suppression at the telogen-to-anagen transition.
- Trichoscopic features of frontal fibrosing alopecia: Results in 249 patients trichoscopic features of frontal fibrosing alopecia described in 249 patients.
- Conditions simulating androgenetic alopecia A review catalogues conditions that mimic androgenetic alopecia and explains their differing causes.
- Intravenous methylprednisolone pulse therapy in severe alopecia areata Monthly methylprednisolone infusions produced a clinical response in 81% of 32 severe alopecia areata patients, best in first-episode multifocal disease.
- Treatment of Alopecia Areata With Topical Sensitizers A review: topical sensitizers (DPCP, SADBE) remain the treatment of choice for severe alopecia areata, with growing evidence on pediatric use and safer delivery.
- Is there a relationship between androgenic alopecia and benign prostatic hyperplasia? A cross-sectional study of 150 older men found no relationship between androgenic alopecia and prostate volume, PSA, or urinary symptoms.
- Fibroblast Growth Factors Stimulate Hair Growth through<i>β</i>-Catenin and Shh Expression in C57BL/6 Mice In mice, topical fibroblast growth factors induced earlier and longer anagen phases via beta-catenin and Shh expression.
- Retrospective Review of Folliculitis Decalvans in 23 Patients with Course and Treatment Analysis of Long-standing Cases In 23 folliculitis decalvans patients, most improved or remitted with oral antibiotics, though some needed years of slow tapering.
- Hair cosmetics: An overview A review describes how shampoos, conditioners, dyes and straighteners work and their side effects, arguing they improve adherence to scalp treatments.
- In vivo visualization of hair follicles by ultrasound biomicroscopy in alopecia areata and its correlation with histopathology. Ultrasound biomicroscopy visualized hair follicles in alopecia areata, matching histology for number and width but underestimating length.
- Osteopontin: a new facilitating factor in alopecia areata pathogenesis? Plasma osteopontin was elevated in alopecia areata patients but did not fall after successful DPCP treatment.
- Role of platelet-rich plasma in chronic alopecia areata: Our centre experience In 20 chronic alopecia areata patients treated with PRP, only one relapsed and none had side effects, though longer studies are needed.
- [Female androgenetic alopecia, a survey of causes and therapeutic options]. A small study of 24 women found mesotherapy improved hair growth and thickness, with density gains mainly in younger women.
- Effectiveness of 308-nm Excimer Laser Therapy in Treating Alopecia Areata, Determined by Examining the Treated Sides of Selected Alopecic Patches In 10 alopecia areata patients, 308-nm excimer laser increased hair diameter versus the untreated half of the same patch.
- Epidermal stem cells and skin tissue engineering in hair follicle regeneration A review of follicle regeneration strategies notes no successful method to grow human hair follicles from adult cells has yet been reported.
- Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population Two aromatase gene (CYP19A1) variants were associated with female pattern hair loss risk in Chinese women.
- Alopecia Areata in the Elderly: A 10-Year Retrospective Study In a 10-year review, alopecia areata in patients over 60 tended to be mild and responded favorably to treatment.
- Study of the international epidemiology of androgenetic alopecia in young caucasian men using photographs from the internet Using dating-site photos, severe AGA affected 15% of young Caucasian men, rising with age and BMI and varying by region.
- Hair Growth Promotion Activity and Its Mechanism of<i>Polygonum multiflorum</i> In mice, oral raw Polygonum multiflorum promoted hair growth via FGF-7 while topical processed form worked via SHH.
- Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population CXCL1 and CXCL2 gene variants were associated with increased alopecia areata risk in a Korean population.
- Normal and Aging Hair Biology and Structure ‘Aging and Hair' A review explains how aging alters hair follicles and fiber structure, and notes minoxidil, finasteride and light therapy aim to counter balding.
- Alopecia Areata A review of alopecia areata: intralesional corticosteroids remain first-line, with systemic steroids, anthralin, minoxidil and immunotherapy as options.
- Effect of Ultraviolet Radiation, Smoking and Nutrition on Hair A review covers how UV radiation, smoking and nutrition affect hair, noting supplements help only when deficiency exists.
- A Hospital-based Study to Determine Causes of Diffuse Hair Loss in Women In 180 women with diffuse hair loss, telogen effluvium was most common (64%), with stress and iron deficiency as leading factors.
- Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression. In mice, blocking the collagenase enzymes MMP-2 and MMP-9 suppressed hair growth and lowered VEGF, IGF-1 and TGF-beta, showing they help regulate the hair cycle.
- Involvement of mechanical stress in androgenetic alopecia A finite-element scalp model found strong correlation between mechanical stress distribution and the Norwood balding pattern, suggesting stress shapes AGA.
- Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles In cultured human dermal papilla cells, herbal extracts increased proliferation and reduced 5-alpha-reductase expression via ERK and Akt signaling.
- Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata In a retrospective comparison, steroid pulse therapy gave good regrowth in 64.6% of severe alopecia areata patients versus 50% on cyclosporine plus steroid.
- Comparative evaluation of Intralesional Triamcinolone Acetonide Injection, narrow band Ultraviolet B, and their combination in Alopecia Areata In 40 alopecia areata patients, intralesional triamcinolone produced over 50% regrowth in 67.5%, clearly beating NB-UVB (17.5%); combining them added nothing.
- Lichen Planopilaris in the Androgenetic Alopecia Area: A Pitfall for Hair Transplantation In 26 patients, lichen planopilaris hid within pattern thinning and was mistaken for seborrheic dermatitis; biopsy is needed before transplant.
- Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial.