December 201518
A review found low-level laser devices effective for male and female pattern hair loss, though trial reporting quality was limited. Topical finasteride 0.25% solution reduced scalp DHT by roughly half with less serum DHT reduction than oral. A five-day wash test counting shed hairs distinguished chronic telogen effluvium from female pattern hair loss without biopsy. Expert consensus proposed the Female Pattern Hair Loss Severity Index, a 20-point scale combining shedding, density and trichoscopy for early grading. Computer simulations of scalp cooling for chemotherapy hair loss found coolant temperature, not cap design, mainly determined tissue temperature.
- Low level laser therapy and hair regrowth: an evidence-based review A review of randomized trials found FDA-cleared low-level laser devices safe and effective for male and female pattern hair loss, though trial reporting quality was limited.
- Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia In two small trials, topical 0.25% finasteride at low doses reduced scalp DHT by ~50% with less serum DHT reduction than oral, potentially lowering systemic side effects.
- Non-invasive method distinguishes chronic telogen effluvium from mild female pattern hair loss: clinicopathological correlation In a 37-patient study, a 5-day wash test counting shed hairs distinguished chronic telogen effluvium from mild female pattern hair loss without biopsy.
- Towards a consensus on how to diagnose and quantify female pattern hair loss – The ‘Female Pattern Hair Loss Severity Index (FPHL-SI)’ An expert consensus proposes the FPHL Severity Index, a 20-point scale combining shedding, density and trichoscopy to grade female pattern hair loss early.
- Topical Ruxolitinib for the Treatment of Alopecia Universalis In a patient with alopecia universalis, topical ruxolitinib 0.6% cream produced significant eyebrow regrowth after 12 weeks.
- Simulation of scalp cooling by external devices for prevention of chemotherapy-induced alopecia Computer simulations of scalp cooling for chemotherapy hair loss found coolant temperature, not cap design, mainly determines tissue temperature.
- The Success of Thread-embedding Therapy in Generating Hair Re-growth in Mice Points to Its Possibly Having a Similar Effect in Humans In mice, thread-embedding therapy enhanced hair regrowth, raising FGF-7 and lowering FGF-5, comparable to a minoxidil group.
- Extensive Hair Shaft Growth after Mouse Whisker Follicle Isolation, Cryopreservation and Transplantation in Nude Mice In mice, cryopreserved whisker follicles retained stem cells and grew extensive hair shafts for 8 weeks after transplantation into nude mice.
- Evaluation of hair growth promoting activity of Phyllanthus niruri. In testosterone-induced alopecia in rats, topical Phyllanthus niruri extract promoted regrowth and inhibited type-2 5-alpha-reductase in vitro.
- Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects In lab skin models, clobetasol-loaded nanocapsules targeted hair follicles and reduced transdermal permeation, potentially minimizing topical steroid adverse effects.
- Rapid skin repigmentation on oral ruxolitinib in a patient with coexistent vitiligo and alopecia areata (AA) a patient with coexisting vitiligo and alopecia areata showed rapid skin repigmentation on oral ruxolitinib.
- Laser Capture Microdissection Reveals Transcriptional Abnormalities in Alopecia Areata before, during, and after Active Hair Loss Laser capture microdissection reveals transcriptional abnormalities in alopecia areata before, during, and after active hair loss.
- Biomarkers of alopecia areata disease activity and response to corticosteroid treatment In scalp biopsies from six alopecia areata patients, Th1 and Th2 markers were elevated and several fell after steroid injection, identifying response biomarkers.
- Effects of the biomimetic peptide Sh-Polypeptide 9 (CG-VEGF) on cocultures of human hair follicle dermal papilla cells and microvascular endothelial cells A lab study examined how the VEGF-like peptide Sh-Polypeptide 9 affects interactions between dermal papilla and endothelial cells.
- Cytokine loaded layer-by-layer ultrathin matrices to deliver single dermal papilla cells for spot-by-spot hair follicle regeneration In mice, dermal papilla cells coated with cytokine-loaded ultrathin matrices regenerated hair follicles at transplanted spots.
- Retrospective review of diphencyprone in the treatment of alopecia areata A 20-year review of diphencyprone for alopecia areata found 72% had some regrowth; less extensive, shorter-duration disease predicted better response.
- Intralesional Triamcinolone Acetonide Versus Topical Betamethasone Valearate in the Management of Localized Alopecia Areata. In a randomized trial of 226 patients with localized alopecia areata, intralesional triamcinolone regrew hair in 74% versus 47% with topical betamethasone.
- Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay In human hair dermal papilla cells, Avicennia marina extract inhibited 5-alpha-reductase, cutting DHT production by 52%.