November 201518
Men with early-onset pattern hair loss had more metabolic syndrome, and hairs in pattern hair loss patients grew slower than thickness-matched controls, slowing further with severity. DPCP in alopecia areata patients achieved over 50% regrowth in most, though 44% relapsed and thyroid disease predicted poor outcomes. Hippocampus-sparing whole-brain radiotherapy fully preserved hair in all six patients studied, and IL-12/IL-23p40 cytokine antagonism was reported to reverse extensive alopecia areata.
- Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy Hippocampus-sparing whole-brain radiotherapy lowered scalp follicle dose and fully preserved hair in all six patients studied.
- Androgenetic alopecia as an indicator of metabolic syndrome and cardiovascular risk In a small case-control study, men with early-onset pattern hair loss—especially vertex balding—had more metabolic syndrome and signs of early atherosclerosis.
- Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism blocking the IL-12/IL-23 p40 cytokine reversed extensive alopecia areata.
- Gender differences in scalp hair growth rates are maintained but reduced in pattern hair loss compared to controls In patients with pattern hair loss, hairs grew slower than equal-thickness hairs in controls, and growth slowed further with worsening severity.
- Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients In 50 alopecia areata patients, DPCP achieved over 50% regrowth in most, though 44% relapsed; thyroid disease predicted poor outcomes.
- A bibliometric study of scientific literature in Scopus on botanicals for treatment of androgenetic alopecia A citation analysis found research on botanicals for pattern hair loss is growing, led by green tea, saw palmetto and similar plants.
- Triggered release of model drug from AuNP-doped BSA nanocarriers in hair follicles using IRA radiation Infrared light triggered drug release from gold-nanoparticle carriers in hair follicles of pig skin, a possible follicle-targeted delivery method.
- The role of oxidative damage in poor scalp health: ramifications to causality and associated hair growth Oxidative stress contributes to dandruff, and a zinc pyrithione shampoo improved scalp condition and hair quality.
- The impact of oxidative stress on hair A review describes how oxidative stress from UV, smoking and pollution damages hair fibers and contributes to age-related hair changes.
- Alopecic and Aseptic Nodules of the Scalp/Pseudocyst of the Scalp: Clinicopathological and Therapeutic Analyses in 11 Korean Patients In 11 young Korean men with scalp nodules and hair loss, antibiotics plus steroid injections were used; consider this diagnosis for alopecic nodules.
- Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice In testosterone-treated mice, Cacumen platycladi extract lowered DHT, blocked 5-alpha-reductase and promoted hair regrowth.
- Mast Cells and Scarring Alopecia: Is There a Clear Pathophysiological Relationship? review asking whether mast cells play a clear pathophysiological role in scarring alopecia.
- Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture In cell culture, herbal PAK1 inhibitors such as cucurbitacin I promoted hair cell growth while suppressing cancer cells and melanogenesis.
- Bad Hair Day: Testosterone and Wnts commentary on how androgen receptor signaling interacts with Wnt pathways in mouse hair follicles.
- From Targets to Treatments: Bridging Autoimmune Research to Advance Understanding of Alopecia Areata A review describes how research summits shifted alopecia areata understanding toward genetic and immunological drivers.
- Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain In alopecia areata mice, a collagen-binding parathyroid hormone analog reduced hair loss (62% vs 30%) by stimulating the hair cycle.
- Current Treatments for Alopecia Areata A review outlines how alopecia areata therapies are selected and notes growing interest in JAK inhibitors and IL-2.
- Development of Uniform Protocol for Alopecia Areata Clinical Trials a standardized clinical-trial protocol template was developed to make alopecia areata studies comparable.