October 201518
Long-term oral finasteride in men showed infrequent sexual side effects, rarely causing discontinuation, in a 130-patient questionnaire study, while finasteride 1 mg in Indian men found no more dysfunction than controls. Topical minoxidil beat placebo for regrowth, with acceptable results in a subset, while 5% minoxidil foam in women was noninferior to 2% solution. Topical adenosine in Caucasian men increased thick hair proportion and density versus placebo. DPCP for alopecia areata helped about half of extensive cases with transient side effects, though evidence quality is very low.
- Oral Finasteride Presents With Sexual-Unrelated Withdrawal in Long-Term Treated Androgenic Alopecia in Men. In a 130-patient questionnaire study, sexual side effects with long-term finasteride were infrequent (3–7%) and rarely caused discontinuation, though this self-selected survey cannot exclude rarer or persistent effects.
- Topical Minoxidil: Systematic Review and Meta-Analysis of Its Efficacy in Androgenetic Alopecia. A meta-analysis confirmed topical minoxidil beats placebo for hair regrowth, but cosmetically acceptable results occur in only a subset of users.
- 5% Minoxidil: treatment for female pattern hair loss. A review: once-daily 5% minoxidil foam, newly FDA-approved for female pattern hair loss, grew hair and was noninferior to 2% solution twice daily.
- Randomized Questionnaire Based Case–Control Research Study on Evaluation of Sexual Function in Indian Patients Taking Oral Finasteride for Androgenetic Alopecia An Indian questionnaire study of 586 men found no more sexual dysfunction on finasteride 1 mg than controls, though self-report surveys may miss effects.
- Prediction of male-pattern baldness from genotypes A genetic model using 14 SNPs predicted early-onset male-pattern baldness at 0.74 accuracy in European men, below clinical usefulness.
- Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia In 38 Caucasian men, topical adenosine increased the proportion of thick hairs and hair density versus placebo over 6 months.
- Improvement of androgenetic alopecia with topical<i>Sophora flavescens</i>Aiton extract, and identification of the two active compounds in the extract that stimulate proliferation of human hair keratinocytes A 6-month randomized trial found topical Sophora flavescens root extract significantly improved alopecia scores versus placebo.
- Pharmacologic inhibition of JAK-STAT signaling promotes hair growth Topical JAK inhibitors rapidly triggered the growth phase and hair growth in mouse and human skin, opening a new treatment avenue.
- Diphenylcyclopropenone in patients with alopecia areata. A critically appraised topic A critical appraisal of 11 case series finds DPCP helps about half of extensive alopecia areata patients, with transient side effects, but evidence quality is very low.
- Appraisal of guidelines for androgenetic alopecia using the Appraisal of Guidelines for Research and Evaluation II instrument An appraisal of five AGA guidelines found the European guideline highest quality and the 1996 American one lowest.
- Evaluation and Management of the Hair Loss Patient in the Primary Care Setting A review outlines how primary care doctors should evaluate and manage hair loss patients, referring difficult cases to dermatology.
- Adenine supplement delays senescence in cultured human follicle dermal papilla cells Adenine supplementation delayed senescence and extended proliferation of cultured human dermal papilla cells via AMPK activation.
- In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss Computer docking predicted ricinoleic acid and four other herbal compounds as potential PGD2-inhibiting hair-loss treatments needing further testing.
- Frontal Fibrosing Alopecia: An Update on Epidemiology and Treatment a review updating the epidemiology and treatment of frontal fibrosing alopecia.
- Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata a functional interpretation of genome-wide association evidence in alopecia areata.
- HAIR LOSS AND REGENERATION PERFORMED ON ANIMAL MODELS A review describes animal models used in hair regrowth research and calls for long-term safety studies.
- Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence In mice, Gab1 signaling was essential for hair cycle progression and keeping follicle stem cells quiescent.
- Scalp Surgery In vitro, follicular-unit grafts grew slower than micrografts (0.23 vs 0.30 mm over 10 days) with equal survival.