July 201521
Hair restoration surgery was found limited by donor supply and graft survival, with solutions outlined. Feily’s grafting method was reported to locate a scalp-necrosis danger zone and aim to prevent it. Scalp DKK-1 levels were found higher in pattern hair loss than controls. Androgen receptor haplotypes showed no link to pattern hair loss in Mexican families. Sebaceous glands in pattern hair loss appeared enlarged, with follicle stem cells preserved. Pulsed corticosteroids in children were reported to give over 75% regrowth in 57% of severe alopecia areata cases, durable at 8 years. An epidemiology review put alopecia areata lifetime risk near 2%, linked to depression and autoimmune disease.
- Hair restoration surgery: challenges and solutions A review outlines hair transplant limits — donor supply, graft survival, hiding surgery signs — and the solutions surgeons use today.
- Feily’s method as a new mode of hair grafting in prevention of scalp necrosis even in dense hair transplantation Analysis of 18 scalp necrosis cases located a danger zone in the central-right parietal scalp; a new grafting method aims to prevent it.
- Assessment of tissue levels of dickkopf-1 in androgenetic alopecia and alopecia areata Scalp DKK-1 protein levels were higher in pattern hair loss and alopecia areata patients than in controls.
- Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model In cultured human hair follicles, Korean Red Ginseng pretreatment protected against chemotherapy-induced premature catagen via p53 and Bax/Bcl2.
- Combined oral pulse and topical corticosteroid therapy for severe alopecia areata in children: a long-term follow-up study In 65 children with severe alopecia areata, pulsed oral plus topical corticosteroids gave over 75% regrowth in 57%, durable at 8 years.
- Lack of concordance and linkage disequilibrium among brothers for androgenetic alopecia and CAG/GGC haplotypes of the androgen receptor gene in Mexican families In 32 Mexican families, androgen receptor CAG/GGC repeat haplotypes showed no link with who developed pattern hair loss.
- Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia) Scalp biopsies from Japanese men with pattern hair loss showed enlarged, multilobed sebaceous glands but preserved follicle stem cells.
- Highly efficient and compatible shampoo for use after hair transplant A mild bisabolol shampoo used after hair transplantation significantly reduced scabbing and redness and was well tolerated.
- Epidemiology and burden of alopecia areata: a systematic review A systematic review finds alopecia areata lifetime risk around 2%, with links to depression, anxiety, atopy and autoimmune disease.
- N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles In cultured human hair follicles, stable spermidine analog N1-methylspermidine prolonged anagen and cut inflammation and oxidative stress.
- Psoriatic alopecia A review explains psoriasis can cause reversible or rarely scarring hair loss, and some psoriasis treatments worsen shedding.
- Hair Growth: Focus on Herbal Therapeutic Agent A review catalogues traditional herbal remedies believed to reduce hair loss and stimulate growth, with proposed mechanisms.
- The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration A review describes how fat tissue, immunity, hormones, aging and daily rhythms modulate hair and feather follicle stem cells.
- Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting? In vitro, chitosan microparticles plus iontophoresis increased minoxidil accumulation in hair follicles sixfold versus plain solution.
- Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining In mice, apoptotic proteins Bim and Puma partially overlap cell death during normal hair follicle development and catagen.
- Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling In mice, Foxp1 restrains hair follicle stem cell proliferation under oxidative stress; its loss extended anagen.
- Benefit of different concentrations of intralesional triamcinolone acetonide in alopecia areata: An intrasubject pilot study a pilot study compared different concentrations of injected triamcinolone acetonide within the same alopecia areata patients.
- Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia Flutamide-loaded solid lipid nanoparticles boosted skin deposition and new follicle growth in hamsters versus standard solution.
- Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route A review finds lipid nanoparticles under 640 nm with sebum-like lipids best target hair follicles for drug delivery.
- Evaluation of serum zinc level in patients with newly diagnosed and resistant alopecia areata Serum zinc was lower in 50 alopecia areata patients than controls, lowest in resistant cases, correlating with severity and duration.
- Advanced glycation end-products inhibit mesenchymal-epidermal interaction by up-regulating proinflammatory cytokines in hair follicles Lab work suggests advanced glycation end-products up-regulate inflammatory cytokines and disrupt dermal papilla signalling in hair follicles.