February 201513
A hair fiber filler product was reported to temporarily improve the appearance of thinning hair, with most surveyed users satisfied. A review of alopecia drug discovery highlighted stem cells, JAK inhibitors and hair follicle neogenesis as future directions across androgenetic, areata and chemotherapy-induced alopecia. In mice, conditioned medium from keratinocyte stem cells was found to increase hair growth and follicle cell proliferation, as was a six-growth-factor cocktail derived from it. In cell co-culture, dermal papilla cells were shown to promote endothelial cell survival and vessel tube formation via VEGF and IGF-1, suggesting a role in follicle vascular remodeling.
- Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib One patient's alopecia areata reversed strikingly on the JAK1/2 inhibitor baricitinib, with mouse data linking improvement to interferon-signature resolution.
- Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells In mice, conditioned medium from keratinocyte stem cells and a six-growth-factor cocktail derived from it increased hair growth and follicle cell proliferation.
- Drug discovery for alopecia: gone today, hair tomorrow A review surveys drug discovery for androgenetic, areata and chemotherapy-induced alopecia, highlighting stem cells, JAK inhibitors and hair follicle neogenesis as future directions.
- Oral isotretinoin as the most effective treatment in folliculitis decalvans: a retrospective comparison of different treatment regimens in 28 patients In 28 folliculitis decalvans patients, oral isotretinoin gave stable remission in 90%, outperforming antibiotic regimens which relapsed quickly.
- Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling In mice, deleting ceramide synthase 4 dysregulates BMP and Wnt signaling, overactivating then exhausting hair follicle stem cells and causing age-related hair loss.
- A Comparison of Reticle Size to Determine Follicular Unit Density in Hair Restoration A comparison of reticle sizes for measuring follicular unit density in hair restoration.
- Patient satisfaction following the use of a hair fiber filler product to temporarily increase the thickness and fullness of thinning hair. In a 40-person satisfaction survey, a topical hair fiber filler product temporarily improved appearance of thinning hair, with 88% satisfied with color match.
- Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells In co-culture, dermal papilla cells promote endothelial cell survival and vessel tube formation via VEGF and IGF-1, suggesting a role in follicle vascular remodeling.
- Optical Coherence Tomography for Planning of Follicular Unit Extraction In three volunteers, optical coherence tomography mapped subcutaneous follicle angles noninvasively, potentially reducing graft transection in follicular unit extraction.
- Folliculitis decalvans: a multicentre review of 82 patients In an 82-patient review of folliculitis decalvans, tetracyclines and clindamycin-rifampicin were the most useful treatments; early onset and pustules predicted severity.
- Analysis of Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid Drug, Colchicine Ex vivo, colchicine inhibited hair fiber elongation and altered 24 dermal papilla proteins, implicating the ubiquitin-proteasome system in its hair-shedding effect.
- Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia In cell culture, balding dermal papilla cells show premature senescence and poor oxidative stress handling, suggesting oxidative stress contributes to androgenetic alopecia.
- Efficacy and safety of diphenylcyclopropenone alone or in combination with anthralin in the treatment of chronic extensive alopecia areata: A retrospective case series In a 47-patient retrospective series, adding anthralin to DPCP raised complete regrowth in chronic extensive alopecia areata from 36% to 72%, with more side effects.