August 201513
A review of adult alopecia treatments concluded randomized trial evidence exists only for androgenetic alopecia. A pathogenesis review proposed that arrector pili muscle detachment from follicle stem cells drives irreversible miniaturization in pattern hair loss. A review of female hair loss treatments found only minoxidil proven by rigorous randomized trials, and suggested dextroamphetamine for inflammatory alopecia. A Turkish community survey reported androgenetic alopecia in 31.8% overall, affecting 47.6% of men and 19.2% of women.
- Treatments options for alopecia A review of treatments for common adult alopecias concludes randomized trial evidence exists only for androgenetic alopecia.
- Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss A review proposes that loss of arrector pili muscle attachment to follicle stem cells drives irreversible miniaturization in androgenetic alopecia.
- An update on the treatment of female alopecia and the introduction of a potential novel therapy A review of female hair loss treatments concludes only minoxidil is proven by rigorous randomized trials, and suggests dextroamphetamine for inflammatory alopecia.
- Prevalence and types of androgenetic alopecia in north Anatolian population: A community-based study. In a Turkish community study, androgenetic alopecia affected 31.8% overall — 47.6% of men and 19.2% of women.
- Female Pattern Hair Loss: a clinical and pathophysiological review A review outlines clinical, dermoscopic and histological features of female pattern hair loss and its variable treatment response.
- Significance of the follicular pathway for dermal substance penetration quantified by laser Doppler flowmetry In six volunteers, a topical vasoactive substance raised skin blood flow within 5 minutes only where follicles were open, highlighting the follicular penetration route.
- Successful treatment of corticosteroid-resistant ophiasis-type alopecia areata (AA) with platelet-rich plasma (PRP) A case report describes robust regrowth with PRP injections in a woman with corticosteroid-resistant ophiasis-type alopecia areata.
- Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing In scalp samples, alopecia areata showed TH1, TH2, IL-23 and IL-9 activation without TH17/TH22, suggesting these pathways as future drug targets.
- Human placental extract exerts hair growth-promoting effects through the GSK-3β signaling pathway in human dermal papilla cells In human dermal papilla cells and rat vibrissa follicles, human placental extract promoted hair growth by inhibiting GSK-3β and delayed catagen.
- Hair growth‐promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/<i>β</i>‐catenin and MAPK pathway In cultured dermal papilla cells and rabbit skin, specific alternating-current settings promoted hair growth via Wnt/β-catenin and MAPK pathway activation.
- Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue In mouse skin, caspase-7 is activated in hair follicles and mast cells with non-apoptotic roles independent of cell death.
- Antimicrobial peptide lysozyme has the potential to promote mouse hair follicle growth in vitro In cultured mouse whisker follicles, the antimicrobial peptide lysozyme promoted hair shaft production by enhancing dermal papilla cell activity.
- Telogen elongation in the hair cycle of <i>ob/ob</i> mice In ob/ob mice the telogen phase persisted from 10 to 24 weeks, suggesting they could model telogen effluvium.