April 201514
Topical adenosine in Japanese men was reported to increase thick-hair ratio, while rosemary oil matched minoxidil 2% hair counts with less itching. Five-year finasteride in Japanese men was reported to improve hair in 99.4% of patients, with younger age predicting better response. A review of 5-alpha-reductase inhibitors concluded younger men report persistent side effects after finasteride 1 mg, and a meta-analysis of finasteride trials found inadequate safety reporting with underdetected sexual side effects. Stem Cell Educator therapy was reported to produce lasting regrowth in moderate to severe alopecia areata.
- Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia In a randomized trial of 102 Japanese men, topical adenosine increased the proportion of thick hairs and self-rated hair thickness more than niacinamide, with no related adverse events.
- Five-year efficacy of finasteride in 801 Japanese men with androgenetic alopecia In 801 Japanese men, finasteride improved hair in 99.4% over 5 years, with younger age and less advanced loss predicting better response.
- Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. In a randomized trial of 100 men, rosemary oil increased hair count as much as minoxidil 2% after 6 months, with less scalp itching.
- Safety concerns regarding 5α reductase inhibitors for the treatment of androgenetic alopecia A review concludes a subset of younger men report persistent sexual and nonsexual side effects after finasteride 1 mg, with animal and human data suggesting mechanisms; prescribers should discuss these risks.
- Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis. A meta-analysis of 34 finasteride trials found none had adequate safety reporting and evidence of systematic underdetection of sexual side effects, so published trials cannot establish finasteride's true safety profile.
- Hair regrowth in alopecia areata patients following Stem Cell Educator therapy In a phase 1/2 study of nine patients, a single Stem Cell Educator treatment produced lasting hair regrowth in moderate to severe alopecia areata.
- Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations In mice, plucking hairs at sufficient density triggers a quorum-sensing immune signal that regrows up to five times more neighboring unplucked hairs.
- Interventions for hirsutism (excluding laser and photoepilation therapy alone) A Cochrane review of 157 trials found low-quality evidence that flutamide and spironolactone reduce hirsutism scores versus placebo.
- Regulation Mechanisms of Hair Growth In mice, topical TPA, UV light, and retinoic acid sped hair regrowth after shaving, while DHT, estradiol, PUVA, and steroids suppressed it.
- Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling In mutant mice, loss of Gsdma3 lets follicles skip telogen via elevated Wnt signaling, revealing a switch controlling the catagen-telogen transition.
- Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis In mouse dermal cell assays, the OVOL1-regulated genes follistatin and SFRP1 are needed for new hair follicle formation.
- Enhancing hair follicle regeneration by nonablative fractional laser: Assessment of irradiation parameters and tissue response In mice, fractional 1,550-nm laser triggers hair regrowth only within a narrow energy-density window; higher settings cause ulcers and scarring.
- Hair Transplant A nursing review outlines causes of hair loss and steps and options for hairline restoration.
- Translational Positioning of Janus Kinase (JAK) Inhibitors in Alopecia Areata A commentary discusses JAK inhibitors as an emerging treatment avenue for alopecia areata based on genetic pathway findings.