December 201416
Cyproterone acetate with ethinylestradiol was reported to stop hair fall in 83% of women with pattern hair loss and acne, with regrowth in 77%. PRP combined with polydeoxyribonucleotide increased hair counts and thickness in women with pattern hair loss, outperforming polydeoxyribonucleotide alone on thickness. A review found reports of irreversible sexual dysfunction and depression from finasteride raise concern but are significantly biased, leaving true long-term risks undefined. In mice, topical peppermint oil was reported to promote hair growth exceeding minoxidil on follicle number, without toxicity signs. Nonbalding occipital and temporal scalp in East Asians with severe pattern hair loss was found to show reduced density and thickness. In mice, dying perifollicular macrophages were found to release Wnt signals activating hair follicle stem cells, with blockade delaying growth.
- Therapeutic efficacy of autologous platelet-rich plasma and polydeoxyribonucleotide on female pattern hair loss In 40 women with pattern hair loss, PRP plus PDRN injections increased hair counts ~23% and thickness ~17%, with the combination beating PDRN alone on thickness.
- Antiandrogenic therapy with ciproterone acetate in female patients who suffer from both androgenetic alopecia and acne vulgaris In 35 women with androgenetic alopecia and acne, three months of cyproterone/ethinylestradiol stopped hair fall in 83% and showed regrowth in 77%, with five adverse events.
- Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring? A review finds reports of irreversible sexual dysfunction and depression from finasteride raise concern but are significantly biased, so larger controlled trials are needed to define true long-term risks.
- Peppermint Oil Promotes Hair Growth without Toxic Signs In mice, topical 3% peppermint oil produced the most hair growth of tested groups, beating 3% minoxidil on follicle number and depth, without toxicity signs.
- Characteristics of nonbalding scalp zones of androgenetic alopecia in East Asians In 265 East Asians, even 'nonbalding' occipital and temporal scalp showed reduced density and thickness in severe androgenetic alopecia subtypes.
- Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells In mice, dying perifollicular macrophages release Wnt signals that activate hair follicle stem cells, and blocking this Wnt output delays hair growth.
- Hair Loss in Women A review outlines how obstetrician/gynecologists can diagnose and manage female pattern hair loss and telogen effluvium.
- Plasmacytoid dendritic cells in alopecia areata: missing link? Plasmacytoid dendritic cells actively producing type I interferons were found around hair bulbs in all 19 alopecia areata cases, absent in androgenetic alopecia.
- iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice Mice with an iRhom2 mutation developed a hairless phenotype from defective TACE maturation and disrupted Notch1 signaling in hair follicles.
- Investigation of oxidative stress in patients with alopecia areata and its relationship with disease severity, duration, recurrence and pattern Patients with alopecia areata had reduced erythrocyte SOD and glutathione peroxidase activity versus controls, supporting oxidative stress involvement, unrelated to severity.
- Treatment of alopecia areata with squaric acid dibutylester A review covers the history, mechanism, efficacy and safety of squaric acid dibutylester, a topical sensitizer for alopecia areata.
- Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice In nude mice, topical Eclipta alba extract enlarged follicles, boosted keratinocyte proliferation and lowered TGF-β1 expression.
- The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo the PDE4 inhibitor apremilast suppressed experimentally induced alopecia areata in human skin in vivo.
- Genetically Induced Cell Death in Bulge Stem Cells Reveals Their Redundancy for Hair and Epidermal Regeneration In mice, genetically killing quiescent bulge stem cells did not impair hair follicle regeneration or wound healing, suggesting these cells are redundant short-term.
- [Your patient complains about hair loss. Contribution of a skin biopsy in noncicatricial alopecias]. A review explains when scalp biopsy is needed to diagnose nonscarring alopecias such as androgenetic alopecia, areata and effluvium.
- Bar code–like hair: Dermoscopic marker of tinea capitis and tinea of the eyebrow