June 20148
Dutasteride in finasteride nonresponders improved hair in 77% of men. Men with persistent sexual side effects after finasteride showed higher androgen receptor density in foreskin tissue than controls, though causation is unproven. Sonography and electron microscopy showed distinct structural abnormalities in androgenetic alopecia hair that may aid diagnosis. In mice, stem-cell-derived Wnt1a activated dermal papilla cells and promoted hair follicle regrowth.
- Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia In an 8-patient case-control study, men with persistent sexual side effects after finasteride showed higher androgen receptor density in foreskin tissue than controls, a first molecular clue, though causation is unproven.
- Effect of dutasteride 0.5 mg/d in men with androgenetic alopecia recalcitrant to finasteride In 35 men not responding to finasteride, dutasteride 0.5 mg/day improved hair in 77%, with transient sexual side effects in 17%.
- Hair Morphology in Androgenetic Alopecia In 33 patients, sonography and electron microscopy showed distinct structural abnormalities in androgenetic alopecia hair that may aid diagnosis.
- Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Oral tofacitinib reversed alopecia universalis in a patient also being treated for plaque psoriasis.
- Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth In mice, stem-cell-derived Wnt1a activated dermal papilla cells and promoted hair follicle regrowth.
- A newly discovered linkage between proteoglycans and hair biology: decorin acts as an anagen inducer A commentary noting decorin accelerates anagen and may hint at new hair-loss therapeutic targets.
- Topical Formulations Containing Finasteride. Part II: Determination of Finasteride Penetration into Hair Follicles using the Differential Stripping Technique In rat skin, a chitosan-based topical finasteride formulation delivered more drug into follicles and epidermis than an anhydrous one.
- Morphological and morphometric study of the androgenetic alopecic scalp using two- and three-dimensional analysis comparing regional differences In cadaver scalps, frontal balding regions held almost only vellus follicles and larger sebaceous glands than occipital regions.