January 201438
Dutasteride 0.5 mg in men outgrew finasteride 1 mg on hair count and width in a randomized trial. The HairMax Lasercomb raised terminal hair density versus sham across four trials, and a 655 nm laser comb improved hair in 28 of 32 patients. Half-head PRP injections added hairs versus placebo; year-long PRP injections raised density, and PRP in nonresponders lifted hair count from 71 to 93 units. Pumpkin seed oil 400 mg daily raised hair counts 40% versus 10% on placebo. Finasteride in hairy Japanese patients worked in 88.9% versus 31.6% of others.
- Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study In four sham-controlled trials, the HairMax Lasercomb raised terminal hair density by ~20-26 vs ~2-9 hairs/cm2 over 26 weeks in men and women.
- A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia In 917 men, dutasteride 0.5 mg grew hair dose-dependently and beat finasteride 1 mg on hair count, width and photos, with similar side effects.
- Efficacy of finasteride for treating patients with androgenetic alopecia who are pileous in other areas: A pilot study in Japan In a small Japanese pilot, finasteride worked in 88.9% of pattern-hair-loss patients hairy elsewhere on the body versus 31.6% of those who were not.
- Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial In 76 men, 400 mg/day pumpkin seed oil for 24 weeks raised hair counts 40% vs 10% on placebo, with similar adverse effects.
- The Effect of Autologous Activated Platelet Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation In a half-head placebo-controlled trial, three monthly PRP injections added about 18 hairs per target area and raised density by 27.7 hairs/cm2.
- Platelet-rich plasma in androgenic alopecia: Myth or an effective tool In 11 patients not responding to minoxidil and finasteride, four PRP sessions raised hair count from 71 to 93 follicular units.
- Use of low-level laser therapy as monotherapy or concomitant therapy for male and female Androgenetic alopecia In 32 AGA patients, the 655 nm laser comb improved hair in 28, alone or combined with minoxidil/finasteride, with no adverse reactions.
- Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period In 20 patients, PRP injections raised hair density for a year (peaking at 3 months) with no major side effects.
- Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells Human iPSCs were differentiated into epithelial stem cells that regenerated hair follicles and shafts in skin reconstitution assays.
- Effect of Adiantum Capillus veneris Linn on an Animal Model of Testosterone-Induced Hair Loss. In testosterone-treated mice, topical Adiantum capillus-veneris reduced hair loss and improved follicle density versus testosterone alone.
- Follicular unit extraction with the Artas robotic hair transplant system system: an evaluation of FUE yield An evaluation of failed harvest attempts when using the Artas robotic system for follicular unit extraction.
- Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model In a DHT-induced mouse model, ginsenoside F2 promoted hair growth and suppressed apoptosis more effectively than finasteride.
- Two cases of stroke associated with the use of finasteride，an approved drug for male-pattern hair loss in Japan Two Japanese men developed stroke while on 1 mg finasteride; Japan's regulator reported 14 thrombosis cases in finasteride users, and the authors suggest estrogen increases may be responsible, though this remains a hypothesis.
- <i>Angelica sinensis</i> Induces Hair Regrowth via the Inhibition of Apoptosis Signaling Topical Angelica sinensis extract regrew hair in mice by reducing keratinocyte apoptosis during catagen.
- Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population In an Indian case-control study, 43.5% of young men with early pattern hair loss had metabolic syndrome versus 2.4% of controls.
- A Clinical Trial to Investigate the Effect of Cynatine HNS on Hair and Nail Parameters In a randomized placebo-controlled trial of 50 women, 90 days of Cynatine HNS keratin supplement significantly improved hair loss, growth, strength, and luster.
- Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm Phospholipid-coated nanoparticles penetrated hair follicles best in pig ear and human skin, with strong in vitro-in vivo correlation.
- In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators In mice, TCF3/4-TLE repressors keep hair follicle stem cells quiescent until Wnt/β-catenin signaling lifts the brake and starts regeneration.
- The efficacy of 3% minoxidil vs. combined 3% minoxidil and Korean red ginseng in treating female pattern alopecia a comparison of 3% minoxidil alone versus combined with Korean red ginseng for female pattern alopecia.
- Signaling Involved in Hair Follicle Morphogenesis and Development A review detailing how Wnt, Shh, Notch and BMP signaling crosstalk governs hair follicle morphogenesis.
- Estrone Sulfate Source of Estrone and Estradiol Formation in Isolated Human Hair Roots: Identification of a Pathway Linked to Hair Growth Phase and Subject to Site-, Gender-, and Age-Related Modulations Human hair roots convert estrone sulfate into active estrogens, a pathway linked to hair growth phase and varying by site, sex, and age.
- Experimental study on Dendrobium candidum polysaccharides on promotion of hair growth In mice, Dendrobium candidum polysaccharides promoted hair growth, possibly via increased VEGF expression in skin cells.
- Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior A review of how extrafollicular signals from dermis, fat and neighboring follicles coordinate collective hair cycling behavior.
- <i>In vitro</i> Assembly Properties of Human Type I and II Hair Keratins In vitro, human hair keratins formed different filament structures depending on type I/II combinations, suggesting distinct roles in hair fiber formation.
- Expression of<i>Sfrp2</i>Is Increased in Catagen of Hair Follicles and Inhibits Keratinocyte Proliferation In mice, Wnt inhibitor Sfrp2 peaks in catagen and suppresses keratinocyte proliferation, suggesting a role in hair regression.
- Follicular unit extraction hair transplant harvest: a review of current recommendations and future considerations A review describing follicular unit extraction hair transplantation, its variations, and potential future advances.
- Dermoscopic Approach to a Small Round to Oval Hairless Patch on the Scalp In 148 patients, dermoscopy distinguished causes of small hairless patches, e.g. tapering hairs and yellow dots in alopecia areata.
- Outcomes of staple closure of the donor area during hair transplant by follicular unit transfer In 50 hair transplant patients, staple closure of the donor area gave an acceptable 1.8 mm average scar but caused notable postoperative discomfort.
- Beyond goosebumps: Does the arrector pili muscle have a role in hair loss? A review proposing the arrector pili muscle helps maintain follicle integrity and may play a role in hair loss.
- The shampoo pH can affect the hair: Myth or Reality? Analysis of 123 shampoos found most exceed pH 5.5; lower-pH shampoos may reduce fiber friction, frizz and breakage.
- North American virginian witch hazel (hamamelis virginiana): based scalp care and protection for sensitive scalp, red scalp, and scalp burn-out A retrospective series of 1,373 patients found a witch-hazel shampoo and tonic well tolerated and helpful for sensitive, irritated scalp, including alongside minoxidil.
- DAPT in the control of human hair follicle stem cell proliferation and differentiation In vitro, Notch inhibitor DAPT promoted proliferation and blocked differentiation of human hair follicle stem cells.
- New aspects of the treatment of alopecia areata A review of current alopecia areata treatments, stressing that therapy must be chosen individually for each patient.
- Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata Autoantibodies in alopecia areata patients preferentially bound free-radical-modified superoxide dismutase, suggesting a new autoimmune target.
- A review of adipocyte lineage cells and dermal papilla cells in hair follicle regeneration A review summarizing adipose-derived cells and dermal papilla cells as potential cell-based approaches to regenerate hair.
- Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study A shampoo with rose petal extract and EGCG worked comparably to ketoconazole and zinc-pyrithione shampoos for scalp seborrheic dermatitis in 75 patients.
- Follicular unit transplantation for the treatment of secondary cicatricial alopecia In 37 Chinese patients, follicular unit transplantation for scarring alopecia achieved a mean 79% graft survival rate with high satisfaction.
- Side-effects from follicular unit extraction in hair transplantation a review of side effects arising from follicular unit extraction in hair transplantation.