August 201415
A 655 nm laser/LED helmet in women raised hair counts 37% more than sham in a trial. Follicle sulfotransferase response testing was found to rule out 95.9% of topical minoxidil nonresponders. Leukocyte-rich PRP injections gave clinically important improvement in 41–55% of pattern-hair-loss patients. Methotrexate in alopecia areata produced over 50% regrowth in 68% of patients, though 33% relapsed. Oral ruxolitinib reversed alopecia areata in mice and three patients, with near-complete regrowth reported. Scalp cooling in a meta-analysis cut chemotherapy-induced alopecia risk by 62%, while topical minoxidil showed no benefit.
- The growth of human scalp hair in females using visible red light laser and LED sources In a 47-woman trial, a 655 nm laser/LED helmet used every other day for 16 weeks raised hair counts 37% more than sham, with no adverse events.
- Clinical utility and validity of minoxidil response testing in androgenetic alopecia Analysis of minoxidil response testing finds a hair-follicle sulfotransferase test rules out 95.9% of nonresponders to topical minoxidil.
- Platelet-Rich Plasma for Androgenetic Alopecia In 64 patients with pattern hair loss, two leukocyte-rich PRP injections gave clinically important improvement in 41-55% of patients at 6 months.
- Efficacy and safety of methotrexate in alopecia areata In 31 alopecia areata patients, methotrexate gave over 50% regrowth in 68%, with no serious adverse effects but 33% relapse.
- Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition In mice and three patients, JAK inhibition with oral ruxolitinib reversed alopecia areata, with near-complete regrowth within 5 months.
- Efficacy of interventions for prevention of chemotherapy‐induced alopecia: A systematic review and meta‐analysis A meta-analysis of 17 trials finds scalp cooling cuts chemotherapy-induced alopecia risk by 62%, while topical minoxidil did not help.
- Dermal Papilla Cells Improve the Wound Healing Process and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells In nude mice, dermal papilla cells in engineered skin grafts improved healing and produced human hair bud-like structures.
- Histopathological investigation of clinically non‐affected perilesional scalp in alopecias detected unexpected spread of disease activities Biopsies of clinically normal scalp near alopecia lesions in 50 patients showed hidden microscopic abnormalities in 66%.
- A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia A humanized mouse model of vitamin D-resistant rickets without alopecia confirms unoccupied VDR protects hair follicles.
- Chronic telogen effluvium and female pattern hair loss are separate and distinct forms of alopecia: a histomorphometric and immunohistochemical analysis Scalp biopsy analysis of 46 women shows chronic telogen effluvium is histologically distinct from female pattern hair loss, without follicle miniaturization.
- Recombinant Goat VEGF164 Increases Hair Growth by Painting Process on the Skin of Shaved Mouse Recombinant goat VEGF164 painted on shaved mouse skin sped up hair regrowth compared with controls.
- Clinical efficacy of diphenylcyclopropenone in alopecia areata: Retrospective data analysis of 50 patients a retrospective analysis of diphenylcyclopropenone efficacy in 50 alopecia areata patients.
- Evaluation and diagnosis of the hair loss patient A continuing-education review outlines history, examination and a diagnostic algorithm for hair loss patients.
- Evaluation and diagnosis of the hair loss patient A continuing-education review describes a systematic trichoscopy approach to distinguishing hair and scalp disorders.
- Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse DGAT1 inhibition caused dose-dependent, reversible sebaceous gland atrophy and alopecia in mice but not dogs, flagging skin monitoring needs for human trials.