May 201410
An evidence-based treatment update concluded oral finasteride in men and topical minoxidil in men and women remain the best-supported pattern-hair-loss treatments. Platelet-rich fibrin matrix injections were reported to raise hair density in pattern-hair-loss patients, with gains fading toward six months. A review of future drug targets argued single-target agents will likely prove insufficient. Parietal whorl position was found to predict vertex loss spread in Korean men, with alopecia progressing mostly within six centimeters behind it. In organ-cultured follicles, caffeine in vitro prolonged anagen and countered testosterone effects, with female follicles more sensitive. After sleeve gastrectomy, low combined zinc and iron predicted fourfold higher hair-loss risk, and zinc supplements stopped loss in most cases.
- Androgenetic Alopecia: An Evidence-Based Treatment Update An evidence-based review finds oral finasteride (men) and topical minoxidil (men and women) remain the best-supported treatments for pattern hair loss.
- Platelet-Rich Fibrin Matrix (PRFM) for Androgenetic Alopecia In 15 patients with pattern hair loss, three monthly platelet-rich fibrin matrix injections raised hair density significantly at 2 and 3 months, with gains fading toward 6 months.
- Potential targets in the discovery of new hair growth promoters for androgenic alopecia A review maps future AGA drug targets — 5α-reductase, androgen receptor, growth-factor genes — and argues single-target agents will likely be insufficient.
- Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles<i>in vitro</i> In organ-cultured human hair follicles, caffeine prolonged anagen, boosted shaft elongation and countered testosterone effects, with female follicles more sensitive than male.
- Predicting the Permanent Safe Donor Area for Hair Transplantation in Koreans with Male Pattern Baldness according to the Position of the Parietal Whorl In 952 Korean men with pattern baldness, parietal whorl position predicted vertex loss spread, with alopecia mostly progressing within 6 cm behind the whorl.
- Hair Loss in Females after Sleeve Gastrectomy: Predictive Value of Serum Zinc and Iron Levels After sleeve gastrectomy, 41% of women lost hair; combined zinc-plus-iron levels below 115 predicted fourfold higher risk, and zinc supplements stopped loss in most cases.
- Avicequinone C Isolated from Avicennia marina Exhibits 5α-Reductase-Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System In human dermal papilla cells, avicequinone C from mangrove inhibited type 1 5α-reductase, halving DHT production at 10 µg/mL.
- 7-Phloroeckol promotes hair growth on human follicles in vitro In cultured human follicles, 7-phloroeckol from brown algae stimulated dermal papilla and root sheath cells and elongated hair shafts via IGF-1.
- Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix In mice, topical Chrysanthemum zawadskii water fraction pushed resting follicles into anagen and stimulated matrix cell proliferation.
- Severe androgenetic alopecia as a proxy of metabolic syndrome in male psoriatic patients older than 59 years In 1073 men with psoriasis, severe pattern hair loss was linked to metabolic syndrome components and family cardiovascular history only in those over 59.