December 201326
A modified microfollicular transplant technique was reported to achieve graft transection and wastage rates below 1%. Scalp micropigmentation in Korean patients was reported to camouflage pattern hair loss and scars with high satisfaction. In a laboratory comparison, a proprietary graft preservation solution kept small transplant grafts viable better than saline or Ringer's lactate. In mice, rice bran supercritical CO2 extract was found to promote hair growth comparably to 3% minoxidil. In alopecia areata mice, a collagen-targeted parathyroid hormone fusion protein was reported to trigger rapid hair regrowth lasting two months.
- Microrefined Microfollicular Hair Transplant A surgical center's modified microfollicular transplant technique, from over 1000 cases, achieved graft transection and wastage rates below 1%.
- <i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid In mice, rice bran supercritical CO2 extract promoted hair growth comparably to 3% minoxidil, raising VEGF, IGF-1 and KGF while lowering TGF-beta.
- Micropigmentation: Camouflaging Scalp Alopecia and Scars in Korean Patients In 43 Korean patients with pattern hair loss or scalp scars, scalp micropigmentation camouflage gave highly satisfactory results in 42, with no adverse effects.
- Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia A review covering how hair follicle cell culture has expanded treatment options and the progress and hurdles of follicular cell implantation for balding scalp.
- Therapy for Alopecia Areata in Mice Using Parathyroid Hormone Agonists and Antagonists, Linked to a Collagen-Binding Domain In alopecia areata mice, a single dose of collagen-targeted parathyroid hormone fusion protein triggered rapid hair regrowth lasting two months.
- The Influence of Preservation Solution on the Viability of Grafts in Hair Transplantation Surgery In a laboratory comparison, a proprietary preservation solution kept small hair transplant grafts viable better than saline or Ringer's lactate.
- Action Mechanism of Chamaecyparis obtusa Oil on Hair Growth In mice, Chamaecyparis obtusa oil raised hair-growth signals (IGF-1, VEGF, SCF) and prolonged anagen, suggesting it promotes hair follicle cell proliferation.
- The human hair: from anatomy to physiology A review summarizing the anatomy and physiology of the different types of human hair and their clinical significance.
- ILK modulates epithelial polarity and matrix formation in hair follicles In mouse studies, integrin-linked kinase was required for hair follicle matrix formation, acting upstream of laminin-511 assembly.
- Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles Ginsenoside Rg3 dose-dependently up-regulated VEGF in human dermal papilla cells and mouse hair follicles, suggesting a hair growth mechanism.
- Quercetin stimulates melanogenesis in hair follicle melanocyte of the mouse. In mouse hair follicle tissue, quercetin increased melanin production by boosting tyrosinase and TRP-2 protein levels.
- A prostaglandind-synthase-positive mast cell gradient characterizes scalp patterning In 11 cadaver scalps, prostaglandin D-synthase-positive mast cells formed a vertex-to-side gradient mirroring pattern hair loss, in balding and non-balding scalps alike.
- Stem cell dynamics in the hair follicle niche A review of mouse genetic studies dissecting the hair follicle stem cell niche and how it regulates regeneration.
- Hair Growth‐Promoting Effect of <i>Carthamus tinctorius</i> Floret Extract Carthamus tinctorius floret extract boosted dermal papilla cell proliferation, growth-factor genes and hair growth in cultured follicles and mice.
- Association between <i>IL16</i> gene polymorphisms and susceptibility to alopecia areata in the Korean population In a Korean population study, two IL16 gene polymorphisms were associated with alopecia areata susceptibility and family history.
- Association of HSPA1B SNP rs6457452 with Alopecia Areata in the Korean Population In a Korean population, an HSPA1B gene variant was associated with alopecia areata onset and possibly reduced susceptibility.
- Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells A lipid nanoparticle ('squarticle') carrier was developed to deliver diphencyprone and minoxidil to hair follicles and dermal papilla cells.
- Morphological changes of the hair roots in alopecia areata: A scanning electron microscopic study Scanning electron microscopy of hair roots revealed four morphology patterns that distinguish alopecia areata, suggesting a less invasive diagnostic approach.
- Pigmented concealing powders for the hair loss patient A review introducing pigmented concealing powders as a practical, natural-looking cosmetic camouflage option for hair loss patients.
- Overview of Alopecia Areata A review of alopecia areata's genetics, immune basis, associated diseases and treatments, noting there is still no cure.
- The Genetic Architecture of Alopecia Areata A review of the genetic architecture of alopecia areata and how genome-wide findings point toward repurposed autoimmune drugs.
- Alopecia Areata: Updates from the Mouse Perspective A review of alopecia areata mouse models highlighting candidate genes and new strains for studying disease mechanisms.
- The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives A review arguing that collapse of hair follicle immune privilege and NKG2D+ cell activity underlie alopecia areata.
- A New Humanized Mouse Model for Alopecia Areata A humanized mouse model of alopecia areata, driven by NKG2D+ cells, reproduces the disease's characteristic hair loss and pathology.
- Current Treatment of Alopecia Areata A review of alopecia areata treatments — steroids, topical immunotherapy, minoxidil, anthralin, immunosuppressants — stressing individualized treatment by age and extent.
- Excimer Laser: A Module of the Alopecia Areata Common Protocol A description of a common protocol module for studying 308-nm excimer laser treatment in moderate-to-severe scalp alopecia areata.