June 201314
Finasteride and dutasteride in a network meta-analysis were found equally effective and not significantly different from placebo for sexual dysfunction, though persistent-dysfunction reports motivated the analysis. A topical-agents review reported minoxidil remains the only approved topical for androgenetic alopecia, with several new agents under investigation. Valproic acid in organ culture promoted human hair shaft elongation in vitro and accelerated anagen in mice. In mice, Fgf9 from dermal γδ T cells was shown to drive wound-induced formation of new hair follicles. In a stem-cell study, CaV1.2 channel blockers were reported to induce anagen and reverse the Timothy-syndrome baldness phenotype.
- The efficacy and safety of 5α-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit–risk assessment of finasteride and dutasteride A network meta-analysis found finasteride 1 mg, 5 mg and dutasteride 0.5 mg equally effective and not significantly different from placebo for sexual dysfunction, though persistent-dysfunction reports motivated the analysis.
- Valproic acid promotes human hair growth in in vitro culture model Valproic acid promoted human hair shaft elongation in organ culture and accelerated anagen in mice by raising β-catenin via GSK-3β inhibition.
- Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding In mice, Fgf9 secreted by γδ T cells drives wound-induced formation of new hair follicles via Wnt activation in fibroblasts.
- State-dependent signaling by Ca<sub>v</sub>1.2 regulates hair follicle stem cell function Calcium channel CaV1.2 controls hair follicle stem cell quiescence via Fstl1; L-type channel blockers induced anagen and reversed the Timothy-syndrome baldness phenotype.
- Topical agents for hair growth promotion: what is out there? A review finds minoxidil remains the only approved topical for androgenetic alopecia, with several new agents under investigation.
- Early stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum In 87 alopecia areata patients, early lesions showed upper-dermis inflammation and infundibulum damage, suggesting the upper follicle is attacked as well as the bulb.
- Effect of intense pulsed light treatment on human skin<i>in vitro</i>: analysis of immediate effects on dermal papillae and hair follicle stem cells Ex vivo IPL mainly destroyed pigmented hair structures while sparing follicle stem cells; dermal papilla damage occurred only at high energies.
- Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers Engineered 3D hair-bulb-like structures formed follicle-like structures when implanted in mice and may serve as a drug-screening platform.
- Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche In 42 lichen planopilaris patients, lesional follicles showed bulge immune-privilege collapse with cytotoxic T-cell attack and stem cell death; IFNγ reproduced this in culture.
- A Comprehensive Approach to Hair Pathology of Horizontal Sections A mnemonic image method for reading horizontal scalp biopsies achieved 92% accuracy in a validation test of pathologists and residents.
- Characterization of Hair Follicle Development in Engineered Skin Substitutes In grafted engineered skin, chimeric human–mouse constructs formed pigmented hairs without sebaceous glands, while human-only cells formed none.
- The incidental pore: Ca<sub>V</sub>1.2 and stem cell activation in quiescent hair follicles A commentary highlighting that calcium channel CaV1.2 acts in hair follicle stem cells to permit anagen re-entry, independently of calcium flux.
- Effect of hairpieces on perceived quality of life in female pattern hair loss patients: Questionnaire based study a questionnaire study examining how hairpieces affect quality of life in women with pattern hair loss.
- Brazilian keratin hair treatment: a review A review warns that Brazilian keratin straightening treatments often contain formaldehyde or its derivatives despite being marketed as safe, with virtually no formal adverse-effect reports.