February 201311
Women with androgenetic alopecia reported far more anxiety and depression than men, with distress tied to emotional state rather than clinical severity. A meta-analysis of baldness patterns found vertex baldness associated with a 25% higher prostate cancer risk, though overall pattern hair loss showed no association. Long-term intralesional triamcinolone was linked to abnormal bone density in half of treated alopecia areata patients, with counseling and monitoring advised above 500 mg. Follicular density reference ranges differed between scarring and nonscarring alopecias but overlapped considerably.
- Health Status, Coping Strategies, and Alexithymia in Subjects with Androgenetic Alopecia In 351 androgenetic alopecia patients, women had far more anxiety and depression than men, and distress related to emotional state more than clinical severity.
- Androgenetic alopecia and risk of prostate cancer: A systematic review and meta-analysis A meta-analysis of seven studies found vertex baldness associated with a 25% higher prostate cancer risk, but overall pattern hair loss was not.
- Bone mineral density in patients with alopecia areata treated with long-term intralesional corticosteroids. Half of 18 alopecia areata patients on long-term intralesional triamcinolone had abnormal bone density; the authors advise counseling and monitoring, especially with cumulative doses over 500 mg.
- Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering A review outlines cell-based strategies to enhance epithelial-mesenchymal interactions for human hair follicle bioengineering, still preclinical.
- Follicular Density and Ratios in Scarring and Nonscarring Alopecia In 700 biopsies, follicular density and ratio reference ranges differed between scarring and nonscarring alopecias but overlapped considerably.
- 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice In cultured human follicles and mice, 6-gingerol suppressed hair shaft growth and prolonged telogen, suggesting it inhibits rather than promotes hair growth.
- Clinical Efficacy of a Cosmetic Treatment by Crescina® Human Follicle Stem Cell on Healthy Males with Androgenetic Alopecia A study of the cosmetic product Crescina Human Follicle Stem Cell in men with androgenetic alopecia.
- The Role of Neprilysin in Regulating the Hair Cycle In mice, blocking the enzyme neprilysin topically suppressed hair growth, suggesting it helps regulate entry into anagen.
- Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors In vitro, bFGF, aFGF and EGF maintained proliferation and multipotency of human hair follicle-derived mesenchymal stem cells.
- Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development In mice, mitochondria-generated reactive oxygen species are required for epidermal differentiation and hair follicle development via Notch and beta-catenin signaling.
- Participation of CD34-enriched mouse adipose cells in hair morphogenesis In mice, CD34-positive adipose-derived cells integrated into dermal sheath and produced more developed hair follicles in reconstituted skin.