September 201316
In a randomized trial, 655-nm low-level laser treatment increased hair counts about 35-39% versus placebo. Follicular unit grafting with finasteride and minoxidil was recommended before and after surgery for lasting restoration in young men. Scalp cooling during chemotherapy was found to cut wig or head cover use by 40% and save €269 per patient. Endocrine cancer therapies were associated with hair loss in 4.4% of patients, highest with tamoxifen at up to 25%, an underreported side effect. In mice, collagen-targeted parathyroid hormone analog PTH-CBD prevented chemotherapy-induced hair loss when given before treatment and partly reversed it after.
- The growth of human scalp hair mediated by visible red light laser and LED sources in males In a 44-man randomized trial, 16 weeks of 655-nm low-level laser treatment increased hair counts about 35-39% versus placebo, with no adverse events reported.
- Hair restoration approaches for early onset male androgenetic alopecia A review recommends combining follicular unit grafting with finasteride and minoxidil before and after surgery for lasting restoration in young men with early hair loss.
- Cost-effectiveness analysis of scalp cooling to reduce chemotherapy-induced alopecia A Dutch analysis found scalp cooling cut wig or head cover use by 40%, saved €269 per patient, and was cost-effective at standard thresholds.
- Alopecia With Endocrine Therapies in Patients With Cancer A meta-analysis of 35 trials (19,430 patients) found hair loss in 4.4% of patients on endocrine cancer therapies, highest with tamoxifen (up to 25%), an underreported side effect relevant to counseling.
- Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model In mice, a collagen-targeted parathyroid hormone analog (PTH-CBD) prevented chemotherapy-induced hair loss when given before treatment and partly reversed it after.
- Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells In rat dermal papilla cells, androgen increased TGF-β1 secretion through reactive oxygen species, an effect blocked by the antioxidant N-acetyl cysteine.
- Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach Discusses dermal papilla signaling in hair follicle development and use of inductive cells for follicle bioengineering.
- Smad1 and 5 but Not Smad8 Establish Stem Cell Quiescence Which Is Critical to Transform the Premature Hair Follicle During Morphogenesis Toward the Postnatal State In mice, deleting BMP effectors Smad1 and Smad5 disrupted hair follicle stem cell quiescence and retarded hair morphogenesis.
- A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients A genome-wide study in breast cancer patients linked a CACNB4 variant (rs3820706) to chemotherapy-induced alopecia, with a 443-fold risk difference between highest and lowest genetic risk groups.
- A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock In organ-cultured human hair follicles, knocking down clock genes BMAL1 or Period1 prolonged the anagen growth phase, identifying potential therapeutic targets.
- Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Hair follicle dermal sheath cells suppress T-cell activation via PD-L1, a mechanism behind follicle immune privilege potentially relevant to alopecia areata.
- Audiological abnormalities in patients with alopecia areata High-frequency sensorineural hearing loss was more common in 51 alopecia areata patients (54.9%) than in matched controls (25.4%).
- Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations In transgenic mice, constitutive Stat3 activation depleted bulge hair follicle stem cells while increasing progenitor populations above the bulge.
- A possible solution for hair loss by inhibiting corticotropin-releasing factor (CRF) receptor from traditional Chinese medicine Computer modeling identified caribine, from traditional Chinese medicine databases, as a candidate CRF-receptor inhibitor for stress-related hair loss.
- Serum granulysin as a possible key marker of the activity of alopecia areata Serum granulysin levels were elevated in alopecia areata patients and correlated with larger bald areas and poorer prognosis, a potential activity marker.
- Hair loss and herbs for treatment A review summarizes herbs proposed as alternative hair-loss treatments, without reporting results.