October 201319
Minoxidil in acute telogen effluvium showed a trend toward less progression to chronic telogen effluvium; diet, iron deficiency and thyroid dysfunction predicted onset. A review of female pattern hair loss recommended 2% topical minoxidil twice daily for at least twelve months and discussed off-label options. A review of hair transplant anesthesia highlighted PRP, ACell and follicular-unit extraction as recent advances. In lab work, dermal papilla cells in 3D spheroids partially restored their signature and induced de novo follicles in human skin. Oral cyclosporine in severe alopecia areata produced significant regrowth in 45%, with shorter disease duration predicting better response.
- Acute telogen effluvium onset event is associated with the presence of female androgenetic alopecia: potential therapeutic implications A retrospective study found diet, iron deficiency and thyroid dysfunction predict ATE with female androgenetic alopecia; minoxidil showed a trend to lower progression to chronic telogen effluvium.
- Female Pattern Hair Loss A review of female pattern hair loss recommends 2% topical minoxidil 1ml twice daily for at least 12 months, and discusses off-label options.
- The effect of oral cyclosporine in the treatment of severe alopecia areata In 25 severe alopecia areata patients, oral cyclosporine produced significant regrowth in 45%, with shorter disease duration predicting better response.
- Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth Human dermal papilla cells grown as 3D spheroids partially restored their signature and induced de novo hair follicles in human skin.
- Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution in vivo In nude mice, 10% PRP increased newly formed follicles (344 vs 288) and shortened time to first hair (18 vs 20 days).
- Hair Transplant and Local Anesthetics A review of hair transplant anesthesia and technique highlights PRP, ACell and follicular-unit extraction as recent advances.
- HSL Attenuates the Follicular Oxidative Stress and Enhances the Hair Growth in ob/ob Mice In ob/ob mice, topical HSL restored full hair coverage by week four by reducing oxidative stress and raising antioxidative enzymes.
- Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures In mouse burn wounds, human alpha defensin 5 enhanced healing, reduced bacteria, and induced hair growth via LGR stem cell migration.
- Hematological and hepatic effects of vascular epidermal growth factor (VEGF) used to stimulate hair growth in an animal model In hamsters, topical VEGF liposome gel sped and thickened hair growth, but biochemical and hematological results showed it was not 100% inert; more toxicity study needed.
- VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro In cultured human outer root sheath cells, VEGF165 acting via VEGFR-2 boosted proliferation and migration and altered adhesion, suggesting a follicle role beyond angiogenesis.
- Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation In cultured balding dermal papilla cells, cepharanthine increased IGF-I secretion about twofold, suggesting a hair growth mechanism.
- CCN2 modulates hair follicle cycling in mice In mice, deleting CCN2 in dermal papillae shortened telogen and increased follicle numbers by destabilizing β-catenin.
- Vitiligo and alopecia areata: apples and oranges? A review finds vitiligo and alopecia areata share immune pathways and genetic risk factors despite targeting different cell types.
- Non-scarring patchy alopecia in patients with systemic lupus erythematosus differs from that of alopecia areata A comparison of 21 SLE and 21 alopecia areata patients found distinct clinical and dermatoscopic features separating the two patchy alopecias.
- OVO Homolog-Like 1, a Target Gene of the Wnt/β-Catenin Pathway, Controls Hair Follicle Neogenesis OVO Homolog-Like 1, a Wnt/β-catenin target gene, controls hair follicle neogenesis.
- miRNA in regulation of skin and hair follicle development A review summarizes how miRNAs regulate epidermal homeostasis and hair follicle development.
- Targeted photochemotherapy in alopecia areata In 7 patchy alopecia areata patients, topical 8-MOP plus targeted UVA gave cosmetically acceptable regrowth on average.
- Preparation and characterization of minoxidil loaded nanostructured lipid carrier gel for effective treatment of alopecia In a lab study, a minoxidil nanostructured lipid carrier gel gave faster onset and prolonged release up to 16 hours in vitro.
- Cause of Androgenic Alopecia An overview questions current understanding of androgenic alopecia causes and offers fresh perspectives.