Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

    March 2012 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Bong Kyu Kim, Hwa Young Lee, Jee Hyun Choi … Sungjoo Kim Yoon
    Studysummary In this study, researchers found that overexpression of the hairless protein in Hr mutant mice disrupts inner root sheath formation by downregulating Dlx3 and associated keratins in hair follicle development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jbc.org →
    Discuss this study in the Community →

    Research cited in this study 16

    1. Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle ˜The œFASEB journal · 2010
    2. Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr) Veterinary pathology · 2010
    3. A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis Mammalian genome · 2009
    4. Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis Nature Genetics · 2009
    5. Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling Development · 2008
    6. Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament Genomics · 2007
    7. Morphologic and Molecular Characterization of Two Novel Krt71 (Krt2-6g) Mutations: Krt71 Rco12 and Krt71 Rco13 Mammalian Genome · 2006
    8. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006
    9. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    10. A Novel Missense Mutation in the Mouse Hairless Gene Causes Irreversible Hair Loss: Genetic and Molecular Analyses of Hrm1Enu Genomics · 2006
    11. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    12. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    13. Keratins of the Human Hair Follicle International review of cytology · 2005
    14. FOXE1, A New Transcriptional Target Of GLI2, Is Expressed In Human Epidermis And Basal Cell Carcinoma Journal of Investigative Dermatology · 2004
    15. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    16. Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle British journal of dermatology/British journal of dermatology, Supplement · 2000

    Related research 6

    1. TRPV3 Gain-of-Function Mutation Impairs Differentiation of Hair Follicle Inner Root Sheath ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    2. Functional Analysis of Keratin Components in the Mouse Hair Follicle Inner Root Sheath British Journal of Dermatology · 2004
    3. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    4. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    5. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    6. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981