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    Did you mean Topical JAK Inhibitors?
    Glossary Topical JAK Inhibitors

    medications applied to skin to block Janus kinase enzymes

    Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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    Research 10 of 1000+

    1. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019 · 277 citations
    2. Topical Janus kinase inhibitors for the treatment of pediatric alopecia areata Journal of the American Academy of Dermatology · 2017 · 83 citations
    3. Topical Janus kinase inhibitors: A review of applications in dermatology Journal of the American Academy of Dermatology · 2018 · 63 citations
    4. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    5. Treatment of alopecia universalis with topical Janus kinase inhibitors – a double blind, placebo, and active controlled pilot study International Journal of Dermatology · 2018 · 49 citations
    6. 43647 Treatment of Refractory Folliculitis Decalvans with the Topical JAK Inhibitor Tofacitinib Journal of the American Academy of Dermatology · 2023
    7. Topical JAK Inhibitors for the Treatment of Alopecia Areata and Vitiligo Current dermatology reports · 2017
    8. Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus Biologics: Targets & Therapy · 2011 · 9 citations
    9. 139 Anti-BCC efficacy of a topical hedgehog inhibitor without adverse effects in BCNS patients in a phase 2 randomized controlled trial 2018 · 1 citations
    10. Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors? International Journal of Dermatology · 2023 · 1 citations
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    Community 10 of 1000+

    1. Recommendation for Topical Androgen Inhibitor While on 0.5mg/Day Dutasteride Community · 20 Oct 2025
    2. Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy Reddit · 6 Jan 2025
    3. Inhibition of collagen synthesis, oral versus topical minoxidil Reddit · 15 Nov 2022
    4. Topical finasteride (P-3074) inhibits scalp DHT up to 70% Reddit · 22 Feb 2026
    5. A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle Reddit · 13 May 2025
    6. Choose your topical antiandrogen and tell me why Reddit · 6 Aug 2024
    7. Topical Dutasteride 0.025% 2ml once a week Reddit · 18 Jul 2024
    8. Can I Use Topical Azelaic Acid & Oral Finasteride At The Same Time? Reddit · 29 Mar 2024
    9. No regrowth after oral min, topical fin, min, and tret: Aggressive diffuse/hairline recession in 2 years Reddit · 29 Aug 2024
    10. Stopped topical Minox and Fin for 2 years, started again and gained my old status back Reddit · 18 May 2024
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    Learn 10 of 26

    1. PP405 mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials
    2. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    3. GT20029 Experimental topical drug designed to break down androgen receptors
    4. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    5. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    6. Procyanidin Plant polyphenol found in apples and grape seeds
    7. Neem Oil Oil from the neem tree, used in traditional remedies
    8. Saw Palmetto Palm-berry extract taken as a supplement
    9. Valproic acid Anti-seizure and mood-stabilising drug
    10. Caffeine Stimulant used in hair shampoos and lotions
    All learn results →