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    Did you mean Topical JAK Inhibitors?
    Glossary Topical JAK Inhibitors

    medications applied to skin to block Janus kinase enzymes

    Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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    1. PP405 mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials
    2. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    3. GT20029 Experimental topical drug designed to break down androgen receptors
    4. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    5. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor