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Hair loss treatments, specifically the use of Alfatradiol as an over-the-counter topical 5AR inhibitor that has been shown to be effective in stopping hair loss without side effects. Other treatments discussed include Minoxidil, finasteride and RU58841.

A user's plan to use Zix and topical finasteride (5AR inhibitors) for hair loss, followed by blood testing before/after. The user has suggested creating a fund to cover part of the cost of their blood tests. Replies to their post discuss the effectiveness of the treatments.

PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

User asks if stacking Alfatradiol and Fluridil is effective for hair loss. Alfatradiol is a weaker, topical 5ar inhibitor, while Fluridil is an anti-androgen preventing DHT binding to hair follicles.

Topical finasteride is almost as effective as oral finasteride with fewer side effects. Users are considering between oral and topical finasteride for hair loss treatment.

User taking 1mg finasteride daily for 2 years, wants to block more scalp DHT. Seeks reference for additional topical DHT blockers like alfatradiol and fluridil.

The post is a 1-year update on hair loss progress using topical minoxidil and finasteride treatments. The user has seen good progress, especially in transitioning from a Norwood 3 to a Norwood 2 hair loss pattern.

The conversation discusses a prescribed hair loss treatment combining 12.5% minoxidil with tretinoin, azelaic acid, and topical finasteride, costing $55 a month. One user criticizes the packaging for degrading tretinoin, another suggests it's an overpriced option and recommends topical dutasteride as an alternative due to its higher molecular weight and lower systemic absorption.

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

A 19-year-old with rapid hair loss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.

Serum DHT is mostly inactive; sebum DHT is a better measure for hair loss. Users discuss using finasteride, dutasteride, and topical treatments like KX826 and RU58841 for better scalp DHT suppression.

The conversation discusses why there are no FDA-approved NSAAs like RU58841 on the market, despite their potential superiority to 5AR inhibitors like finasteride. It explores the effectiveness of treatments like Minoxidil, finasteride, and RU58841 for hair loss.

The conversation is about someone who has been taking finasteride for hair loss without success, considering switching to dutasteride or giving up treatment. Suggestions include trying dutasteride, microneedling, infrared therapy, multivitamins, and high-concentration topical solutions combining finasteride and dutasteride.

The user experienced hair loss due to a crash diet and later developed scarring hair loss. They are now on finasteride, oral minoxidil, LDN, Zyrtec, and Oztela to reduce scalp inflammation and promote hair regrowth.

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

Minoxidil can prevent hair follicle miniaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.

User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

A 19-year-old is experiencing hair loss and considering treatments like finasteride, oral minoxidil, and possibly dutasteride. Users suggest continuing with finasteride and minoxidil, with some recommending dutasteride for stronger results.

Hair loss treatments discussed include finasteride, minoxidil, and dermarolling. Users advise patience, noting initial shedding is common and treatments take time to show results.

The conversation is about someone's 4-month hair regrowth progress using 0.5mg dutasteride and topical minoxidil. Another person is inspired and is using 5mg finasteride and 5% minoxidil topically twice daily, hoping for similar results.

The post discusses a user's successful hair regrowth after 3 months using 1 mg oral finasteride, oral minoxidil, weekly 1.5mm derma rolling, and Nizoral shampoo every other day, with no side effects. The conversation includes various responses, questions about the user's ethnicity and previous scalp condition, and suggestions for topical treatments.

A user plans to experiment with creating new hair follicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

The post and conversation are about a user's experience with hair loss treatments, specifically switching from finasteride to dutasteride. The user experienced significant hair shedding after the switch, with others suggesting patience, noting similar experiences, or questioning the user's decision and medical consultation.

A 19-year-old experienced worsening hair loss after 4 months on finasteride, despite initial improvement with minoxidil. The consensus is to continue treatment for at least a year, as shedding is common and often temporary.

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.