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Glossary Systemic Antiandrogens

medications that reduce male hormone effects body-wide

Systemic antiandrogens are medications that reduce the effects of androgens (male hormones) throughout the entire body. They are commonly used to treat conditions like androgenic alopecia (hair loss), prostate cancer, and severe acne by blocking androgen receptors or inhibiting androgen production. These therapies can be crucial for managing hormone-related disorders and are often referred to as systemic anti-androgen therapy.

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Research

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research Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women*

78 citations , May 1989 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that in hirsute women, daily treatment with 200 mg spironolactone significantly reduced hair growth rates and hair shaft diameters on various body areas over 12 months.

research Dermatologic Side Effects of Systemic Targeted Anticancer Therapy

January 2018 in “Springer eBooks”

This chapter reviews the skin side effects associated with targeted cancer therapies and emphasizes the importance of collaboration between oncologists and dermatologists without reporting new results.

research Dermatological medications and local therapeutics

4 citations , September 2014 in “Elsevier eBooks”

This review discusses the safety of dermatological medications used during pregnancy, highlighting that retinoids have strong teratogenic risks and should be used with caution; it reports no new clinical results.

research Systemic treatment options for androgenic alopecia

March 2026 in “Lithuanian University of Health Sciences”

In this study, a systematic review found that for androgenetic alopecia, systemic treatments like finasteride, dutasteride, and oral minoxidil are effective at slowing progression and promoting hair regrowth, with additional antiandrogen therapy options for women.

research THERAPEUTIC APPROACHES TO THE MANAGEMENT OF COMMON BALDNESS

2 citations , July 1999 in “International Journal of Clinical Practice”

This article discusses the various cosmetic, medical, and surgical treatment options for androgenetic alopecia but reports no new clinical findings, emphasizing the importance of differential diagnosis in treatment planning.

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Community Join

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community Starting Propecia with pre-existing erecticle dysfunction

4 upvotes 9 years ago

A 19-year-old with diffuse hair thinning and erectile dysfunction is considering starting Propecia (finasteride) while already using a minoxidil solution with anti-androgens. Concerns are raised about the psychological nature of erectile dysfunction and the potential systemic effects of anti-androgens, with suggestions to address porn addiction and consult a doctor about hormone therapy.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 1 year ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community Does RU58841 potentially cause cancer?

in Research/Science 1 year ago

RU58841 may pose cancer risks due to its antiandrogen properties and lack of long-term safety data. Using it is considered a high-risk experiment with unknown potential for harm.

community There’s nothing better on the horizon [RANT]

22 upvotes 1 month ago

There is skepticism about new hair loss treatments, with the belief that current options like minoxidil, finasteride, and hair transplants are the best available. Concerns are raised about the systemic side effects of androgen-related treatments, even those marketed as topical, and doubts about the effectiveness of emerging treatments like clascoterone.

community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

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