179 citations
,
September 1998 in “BMJ” Hair loss in men is common, treatable, but not curable.
227 citations
,
January 1998 in “Journal of Endocrinology” Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
72 citations
,
September 1997 in “Dermatologic Surgery” Careful planning and patient counseling can lead to excellent hair transplant results, often in one or two sessions.
416 citations
,
September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
18 citations
,
January 1997 in “British Journal of Dermatology” 5% topical minoxidil can cause severe body hair growth, which disappears after stopping treatment.
234 citations
,
December 1996 in “Journal of The American Academy of Dermatology” Middle-aged women with chronic telogen effluvium experience increased hair shedding but usually don't get significantly thinner hair.
19 citations
,
March 1996 in “British Journal of Dermatology” Balding hair follicle cells are smaller, grow less well, and need more effort to culture than non-balding cells.
124 citations
,
January 1996 in “Dermatology” The document discussed the 5 alpha-reductase enzyme system, which metabolizes testosterone into dihydrotestosterone and exists in two isoforms: type 1 and type 2. Type 1 is primarily found in skin-related cells, while type 2 is located in reproductive tissues and hair follicles. The genes for these isozymes are located on chromosomes 5p and 2p. Over the past decade, various inhibitors have been developed to target 5 alpha-reductase activity. Finasteride, which targets the type 2 isozyme, was introduced for treating benign prostate hyperplasia. However, the clinical evaluation of 5 alpha-reductase inhibitors, particularly those targeting type 1, in dermatology was limited. These inhibitors, such as MK-386 and LY191704, were considered potential treatments for androgen-dependent skin disorders, including seborrhoea, acne, hirsutism, and androgenetic alopecia.
80 citations
,
January 1995 in “The American Journal of Medicine” Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.
43 citations
,
July 1994 in “Archives of Dermatology” People with androgenetic alopecia have more personality disorders and mental health symptoms; treatment may help.
222 citations
,
October 1993 in “Journal of The American Academy of Dermatology” Hair loss affects women's mental health more than men's, causing anxiety, low self-esteem, and social insecurity.
309 citations
,
May 1993 in “Journal of The American Academy of Dermatology” Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.
192 citations
,
June 1992 in “Journal of The American Academy of Dermatology” Hair loss can cause low self-esteem, anxiety, and depression in men.
58 citations
,
September 1991 in “British Journal of Dermatology” Women with AGA often face anxiety, depression, and low self-esteem; psychological support is important.
94 citations
,
July 1991 in “Clinical endocrinology” Cyproterone acetate at 2mg daily is as effective as higher doses for treating excessive hair growth in women.
23 citations
,
April 1991 in “Journal of The American Academy of Dermatology” Minoxidil solution can cause skin irritation and allergies in some users.
70 citations
,
April 1990 in “Journal of The American Academy of Dermatology” Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.
78 citations
,
May 1989 in “The Journal of Clinical Endocrinology & Metabolism” Spironolactone effectively reduces hair growth in women with hirsutism and is generally well-tolerated.
21 citations
,
October 1988 in “Clinics in Dermatology” The study used monkeys to test a hair loss treatment called minoxidil, which showed positive results.
143 citations
,
October 1988 in “Clinics in Dermatology” The document discussed the uncertainties and controversies surrounding the histopathology of male-pattern baldness (MPB), also known as androgenetic alopecia, in 1988. While it was agreed that hair follicles become progressively smaller or miniaturized, there was debate over whether there was an actual loss of follicles. Additionally, there were conflicting views on the condition of sebaceous glands and the fate of arrector pili muscles. Despite substantial knowledge of scalp anatomy and hair cycling, the histopathological understanding of MPB remained unclear, and significant publications on aging did not address hair-related changes.
130 citations
,
May 1988 in “Journal of The American Academy of Dermatology” "Male-pattern" hair loss is common in women, especially after menopause, and doesn't always mean there's a problem with hormone balance.
51 citations
,
March 1987 in “Journal of The American Academy of Dermatology” Minoxidil keeps most hair growth from first year and twice-daily use is better with few side effects.
52 citations
,
March 1987 in “Journal of the American Academy of Dermatology”
19 citations
,
March 1987 in “International Journal of Dermatology” A drug called cimetidine can help treat hair loss in women by blocking androgen receptors. However, it's not the first choice and needs more research.
13 citations
,
September 1986 in “Archives of Dermatology” Women with more 3α,17β-androstanediol glucuronide compared to sex hormone binding globulin are more likely to have female pattern baldness.
101 citations
,
January 1985 in “British Journal of Dermatology” Spironolactone is effective for treating acne, hirsutism, and androgenic alopecia in women with few side effects.
203 citations
,
November 1984 in “Journal of the American Academy of Dermatology” The document challenged the widely accepted view that androgenetic alopecia was caused by an autosomal dominant gene with reduced penetrance in women, as proposed by Osborn in 1916. Instead, it presented five arguments supporting a polygenic inheritance model: the high prevalence of the trait, the distribution of balding patterns along a Gaussian curve, the increased risk with more affected relatives, the slightly higher risk for relatives of severely affected women, and the greater importance of maternal inheritance. The study concluded that the simple Mendelian model of inheritance could no longer be upheld.
80 citations
,
September 1984 in “Journal of The American Academy of Dermatology” 5% minoxidil helps hair regrowth in androgenic alopecia.
43 citations
,
July 1984 in “Clinical and Experimental Dermatology” Antiandrogen therapy helped increase hair growth in women with hormonal imbalances related to baldness.
666 citations
,
September 1977 in “British Journal of Dermatology” Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.