13 citations,
January 2020 in “Scientific Reports” The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.
1 citations,
June 2023 in “Biomolecules & therapeutics” Nitric oxide is important for skin functions and both helps protect against and contributes to skin inflammation and sensitization.
January 2025 in “PLoS ONE” Aligned membranes improve wound healing by reducing scars and promoting skin regeneration.
162 citations,
July 2011 in “Biomacromolecules” Chitosan nanofiber scaffolds improve skin healing and are promising for wound treatment.
3 citations,
January 2012 in “Elsevier eBooks” Burn scars form abnormally due to changes in wound healing, and more research is needed to improve treatments.
February 2018 in “Trends in Immunology” Skin bacteria can help wound healing by activating certain immune cells.
7 citations,
November 2020 in “Experimental Dermatology” Different cell types work together to repair skin, and targeting them may improve healing and reduce scarring.
31 citations,
November 2020 in “International journal of molecular sciences” Adipokines affect skin health and could be targeted for treating skin diseases.
42 citations,
May 2016 in “Annual Review of Cell and Developmental Biology” Fat cells are important for tissue repair and stem cell support in various body parts.
5 citations,
December 2014 in “Polish Journal of Public Health” Zinc is essential for many body functions and imbalances can lead to health problems.
2 citations,
December 2023 in “International journal of molecular sciences” Wound healing is greatly affected by the types of bacteria present, which can either help or hinder the process.
6 citations,
May 2022 in “Colloids and Surfaces B: Biointerfaces” Eating peptides from certain shellfish may help wounds heal faster by reducing inflammation.
February 2024 in “International journal of molecular sciences” Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.
113 citations,
June 2019 in “F1000Research” Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.
9 citations,
January 2018 in “Acta dermato-venereologica” A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.
61 citations,
September 2020 in “Bioactive Materials” A special dressing called FEA-PCEI can speed up wound healing, reduce scars, and help grow new hair follicles, but only at the right dosage.
38 citations,
June 2019 in “International Journal of Molecular Sciences” Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.
Wound healing involves three phases and various cells and factors, with scars typically forming in adults. Chronic wounds can occur due to various issues, and abnormal scarring can lead to hypertrophic or keloid scars. Emerging research areas include the role of proteins, microRNAs, macrophage manipulation, and stem cell treatment.
55 citations,
April 2018 in “Advanced Healthcare Materials” Hydrogels could lead to better treatments for wound healing without scars.
276 citations,
December 2017 in “Journal of Dermatological Science” The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.
31 citations,
January 2021 in “Experimental Dermatology” Skin organoids are a promising new model for studying human skin development and testing treatments.
January 2024 in “Journal of developmental biology” Abdominal skin heals faster than dorsal skin because it has more stem cells.
6 citations,
May 2023 in “International journal of molecular sciences” Collagen-enhanced mesenchymal stem cells significantly improve skin wound healing.
13 citations,
June 1999 in “Seminars in cutaneous medicine and surgery” Using topical agents before and after cosmetic surgery improves the results.
124 citations,
June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
April 2018 in “Journal of Investigative Dermatology” Lymphocytes, a type of immune cell, are crucial for wound healing as they help remodel damaged areas and reduce inflammation.
April 2017 in “Journal of Investigative Dermatology” Eating a lot of fat increases PKCβ and inflammation in skin fat cells, which affects skin and hair health.
Aging disrupts skin repair and stress responses, but exercise-related IL-15 improves wound healing and skin health in older skin.
92 citations,
September 2015 in “Journal of Lipid Research” Skin fat helps with body temperature control and has other active roles in health.
24 citations,
May 2019 in “PLOS ONE” The African spiny mouse can fully regenerate its muscle without scarring, unlike the common house mouse.