Toll-Like Receptor 3 Agonist, Polyinosinic-Polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

    January 2018 in “ Acta dermato-venereologica ”
    Bani Kaur Suri, Navin Kumar Verma, Artur Schmidtchen
    Image of study
    TLDR A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.
    The study from 2018 examined how toll-like receptor (TLR) agonists and cytokines affect carbonic anhydrase II (CA II) levels in human primary keratinocytes. It was discovered that the TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C)) significantly increased CA II expression at both mRNA and protein levels. Similarly, Th2 cytokines such as interleukins -4 and -13 also caused a significant rise in CA II expression. These results indicate that CA II might be involved in TLR3-mediated pathways and in the inflammatory response of skin conditions associated with Th2 cytokines. The study suggests that CA II could have roles in antiviral defense, wound healing, and skin regeneration, but it also acknowledges that the upregulation of CA II might be an indirect consequence of other cytokines activated by TLR3. Further research is necessary to clarify CA II's specific functions in skin health and disease.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 57 results

      community Hairloss is mentally exhausting

      in Chat  25 upvotes 4 years ago
      The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 2 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

      community I think we all hop on estrogen. It's the only angle

      in Satire  83 upvotes 4 months ago
      The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

      community C’est terrible - at my wits end

      in Female  449 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

    Similar Research

    5 / 824 results