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Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

Improving insulin sensitivity and weight loss can help manage polycystic ovary syndrome (PCOS).

PCOS is often linked to insulin resistance and obesity, and weight loss can improve symptoms.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Human body's immune cells are more common in the layer of fat just beneath the skin than in deeper fat layers.

Women with PCOS have more body fat and thicker fat layers in certain abdominal areas than women without PCOS.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

Different parts of the body's fat tissue have unique cell types and characteristics, which could help treat chronic wounds.

Dermal adipose tissue in mice can change and revert to help with skin health.

Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.

Fat cells are important for tissue repair and stem cell support in various body parts.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Girls with PCOS during adolescence have a higher risk of developing type 2 diabetes, and early treatment can help manage this risk.

Aquaporins could be new drug targets for treating polycystic ovary syndrome.

Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Identified genes linked to male-pattern baldness may help develop new treatments.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.