45 citations
,
August 1954 in “Experimental Biology and Medicine” This study found that vitamin A dissolved in alcohol penetrates skin quickly and does not impair hair growth, even in large doses, but it does not retard keratinization unlike when dissolved in fatty acids.
44 citations
,
January 2021 in “Research” This study explored the use of manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (MCSA hydrogels) for treating melanoma and promoting wound healing, finding that these hydrogels effectively ablate melanoma under near-infrared irradiation and enhance vascular endothelial cell activity for tissue regeneration.
44 citations
,
January 2019 in “Journal of Translational Medicine” This study found that macrophages are crucial for skin regeneration during tissue expansion, as their depletion in rats led to inhibited skin growth and reduced secretion of key growth factors.
43 citations
,
July 2019 in “Stem Cells International” This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.
42 citations
,
April 2012 in “Seminars in Oncology” This review discusses the skin side effects associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for empirical management based on expert opinion.
42 citations
,
February 2014 in “Stem Cells and Development” This study found that vitamin C increased the survival, proliferation, and hair-regenerative potential of adipose-derived stem cells through the MAPK pathway and enhanced hair growth in mice.
42 citations
,
December 2011 in “The journal of immunology/The Journal of immunology” In this study, transgenic mice with Rank expression in hair follicles showed excessive lymph node growth, which could be normalized by neutralizing the overproduced RANKL, underscoring its role in immune system regulation.
41 citations
,
October 2017 in “International Journal of Women's Dermatology” This review provides an overview of the physiologic skin changes during pregnancy but reports no new findings, emphasizing the need for physicians to distinguish between benign and potentially pathological conditions.
40 citations
,
June 2013 in “Molecular Pharmaceutics” This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.
39 citations
,
November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
37 citations
,
November 2019 in “Journal of Microbiology and Biotechnology” This study found that loliolide enhanced hair growth-related functions in 3D dermal papilla spheroids by activating AKT/β-catenin signaling pathways, with increased expression of related growth factors and genes.
37 citations
,
October 2017 in “Clinical and Experimental Dermatology” This article discusses the potential of oral tofacitinib as a treatment for atopic dermatitis, alopecia areata, and vitiligo, without presenting new clinical results.
37 citations
,
October 2009 in “Dermatology” This study suggests that the action of minoxidil in stimulating hair growth likely occurs at the follicular dermal papilla, though it does not induce new follicle formation.
36 citations
,
November 1961 in “Archives of Dermatology” This abstract discusses the uncertain role of the vascular system in hair loss and highlights the unexplained aspects of various types of alopecias; it reports no new research findings.
36 citations
,
August 2022 in “Molecular Therapy — Nucleic Acids” This review discusses various gene therapy and non-viral delivery methods to promote angiogenesis for chronic wound healing, but it reports no new clinical results.
36 citations
,
February 2017 in “BMC Complementary and Alternative Medicine” In this study, Geranium sibiricum L. extract promoted hair growth in vitro with human dermal papilla cells and in vivo in mice, outperforming minoxidil by proliferating cells and stimulating growth factor expression, suggesting its potential as a hair growth treatment.
36 citations
,
December 2012 in “Dermatologic Surgery” Injecting platelet-rich plasma (PRP) can increase hair growth rate and density in male pattern baldness.
35 citations
,
December 1979 in “Naunyn-schmiedebergs Archives of Pharmacology” These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
35 citations
,
February 2015 in “Experimental Dermatology” This study found that human follicle dermal papilla cells promote survival, proliferation, and tubulogenesis of microvascular endothelial cells, highlighting their significant role in hair follicle vascular remodeling.
35 citations
,
October 2014 in “Wound Repair and Regeneration” This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.
35 citations
,
October 2013 in “Journal of Dermatological Science” This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.
35 citations
,
October 2003 in “Dermatologic clinics” This article discusses the lack of national credentialing for laser therapy practitioners and emphasizes the need for rigorous self-assessment and expertise, particularly when treating patients with darker skin, without presenting new research results.
35 citations
,
January 1993 in “International Journal of Dermatology” In this study, most hair disorders among HIV-1 positive patients were associated with low helper T cell counts, with papulosquamous conditions like seborrheic dermatitis and psoriasis being the most common.
34 citations
,
April 2016 in “International Journal of Dermatology” In this study, certain trichoscopic features were found to be sensitive and specific for diagnosing primary cicatricial alopecias and its subtypes using dermatoscopy.
34 citations
,
January 2014 in “International Journal of Trichology” This study reported that polarized dermoscopy was better for visualizing vascular patterns, scaling, and reticular pigmentation, while nonpolarized mode better documented features like black dots and tapered hair in various hair and scalp conditions.
33 citations
,
October 2016 in “Photomedicine and laser surgery” This review discusses the development of IPL devices, highlights their established cosmetic uses, such as treating vascular and pigmented lesions, and suggests potential expansion into more effective combination therapies.
33 citations
,
May 2006 in “Journal of Investigative Dermatology” This study found that high levels of parathyroid hormone-related protein expression can result in the production of shorter hair shafts, likely through effects on angiogenesis.
33 citations
,
January 1991 in “The Journal of Dermatologic Surgery and Oncology” This article describes incisional slit grafting as an improved hair transplantation method, using smaller grafts and conserving vascular supply to enhance graft yield and achieve a more natural hairline, but reports no new research results.
32 citations
,
May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
32 citations
,
June 2015 in “PLOS ONE” This study demonstrated that topical oleuropein induced hair growth in mice by activating the Wnt10b/β-catenin signaling pathway and increasing expression of several growth-related genes in skin tissue.