10 citations
,
August 2018 in “Experimental Dermatology” This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.
10 citations
,
January 2001 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” In this study, autophagy was commonly observed during keratinization in neonate rat hair follicles, suggesting lysosomal proteases and cytoplasmic enzymes may coordinate in hair follicle cell differentiation.
10 citations
,
October 2000 in “PubMed” This study found that transgenic mice expressing HPV E6/E7 in the outer root sheath experience continuous hair follicle cycling due to delayed catagen entrance and insensitivity to telogen resting signals.
9 citations
,
June 2020 in “BMC Molecular and Cell Biology” This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.
9 citations
,
January 2008 in “Acta histochemica et cytochemica” This study found that COX-2 expression in normal rat skin is linked to the hair cycle, with varying levels observed in different skin structures during anagen, catagen, and telogen phases.
9 citations
,
August 2007 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” This study observed that amino acid uptake into wool follicles varies significantly, with cysteine showing the highest uptake rate, suggesting specialized transport systems that may influence wool growth.
8 citations
,
February 2014 in “Stem cells translational medicine” This study found that human mesenchymal stem cells overexpressing JAM-A improved hair follicle structure and hair formation in mice by reducing abnormalities such as curved and zigzagged follicles.
8 citations
,
January 2014 in “Annals of Dermatology” This study found that TGF-β1 expression in follicular tumors correlates with differentiation degree and suggests its potential role alongside p63 in differentiating between sebaceous and follicular tumors.
7 citations
,
November 2022 in “Communications biology” This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.
7 citations
,
January 2022 in “Biomedicines” In this study, hair follicle-derived mesenchymal stromal cells showed potential for immunomodulation, with equivalent or superior responses compared to those from adipose tissue, suggesting a promising alternative cell source.
5 citations
,
March 2001 in “Journal of biomechanics” This study found that anagen hairs require less force to be extracted than telogen hairs in an in vitro pig skin model, indicating different anchorage mechanisms.
3 citations
,
August 2020 in “International Journal of Molecular Sciences” This study found that Rab27a and Rab27b play opposite roles in hair growth, with Rab27a knockdown suppressing and Rab27b knockdown promoting hair growth in models.
2 citations
,
September 2022 in “Organoid” In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.
2 citations
,
June 2022 in “International Journal of Molecular Sciences” This study found variable outcomes in hair loss treatment with autologous cell-based therapy using DSC cells, with certain gene markers showing inconsistent correlations with treatment efficacy.
2 citations
,
January 2020 in “BioMed Research International” This study found that Phaeodactylum tricornutum extract enhanced hair follicle cell proliferation, indicated by increased keratin and ERK1/2 signaling, suggesting its potential for hair care applications.
2 citations
,
March 2019 in “Journal of Histochemistry and Cytochemistry” This study found that NNAT is localized in both undifferentiated and differentiated cells across various rat tissues and has cell-specific intracellular localization, suggesting distinct functional roles.
2 citations
,
August 2012 in “Journal of the American Academy of Dermatology” This correspondence describes two patients with both epidermolysis bullosa simplex, Dowling-Meara type, and loose anagen hair syndrome, an association not previously reported in the literature.
1 citations
,
January 2021 in “Processes” This study adapted a method for culturing melanocytes from human hair follicles to horses, successfully creating partially melanotic equine melanocytes, potentially advancing hair follicle biology research across species.
1 citations
,
July 2019 in “Small ruminant research” This study suggests that the NGF/TrkA/CREB system plays a crucial role in promoting outer root sheath cell proliferation in cashmere goats, which may aid in marker-assisted breeding.
1 citations
,
May 2017 in “InTech eBooks” This chapter reviews signaling pathways related to androgenic alopecia in dermal papilla cells of balding human scalps, integrating published information and analysis of molecular interactions, without reporting new clinical results.
1 citations
,
December 2015 in “Journal of the Medical Sciences (Berkala Ilmu Kedokteran)” This review discusses transplantation of melanocyte stem cells for vitiligo treatment and reports no new clinical results; it suggests the procedure could be effective in reactivating melanocyte precursors for repigmentation.
1 citations
,
January 1995 in “Skin Cancer” This study suggests that immunohistochemistry of keratin and involucrin expression can aid in distinguishing malignant trichilemmoma from other tumors previously diagnosed as such.
This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.
June 2026 in “Frontiers in Cell and Developmental Biology” In this study, researchers used single-cell RNA sequencing to map the hair follicle microenvironment in fine-wool sheep, identifying specific cell types and gene expressions that influence wool fiber diameter, with dermal papilla cells playing a significant role in hair follicle development.
March 2026 in “Journal of Bioscience and Bioengineering” Oxytocin from hair cells helps hair growth and stem cell increase.
February 2026 in “Nature Communications” This study combined spatial and single-cell transcriptomics to identify that hypercontractility of the connective tissue sheath activates PIEZO1 in hair follicles, leading to miniaturization in male androgenetic alopecia, and found that inhibiting this contraction improves hair growth in models.
November 2025 in “Stem Cell Research & Therapy” This study suggests that human DSCCs may aid in hair follicle regeneration and reduce microinflammation, with potential applications in regenerative medicine evaluated through a new morphometric analysis.
January 2025 in “Dermatology Review” The authors report a rare case of trichilemmal carcinoma in the thigh of a 71-year-old, emphasizing the importance of complete surgical excision to prevent recurrence and support patient prognosis.
October 2024 in “SPIRE - Sciences Po Institutional REpository” This study highlights that human hair follicle dermal papilla cells and glypicans play crucial roles in regulating hair follicle stem cell differentiation.
July 2024 in “Frontiers in Pharmacology” This study suggests that pilose antler extracts promote hair regrowth in androgenetic alopecia mice by activating the AKT and Wnt pathways, enhancing hair follicle stem cell proliferation.