Trichilemmoma: Features of Keratin Expression in CS-5 Trichocyst System Tumors
January 1995
in “
Skin Cancer
”
Studysummary This study suggests that immunohistochemistry of keratin and involucrin expression can aid in distinguishing malignant trichilemmoma from other tumors previously diagnosed as such.
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The study explored the histologic and immunohistochemical features of trichilemmoma and its malignant counterpart, malignant trichilemmoma (mTr), which are tumors differentiating into the outer root sheath (ORS) of hair follicles. It was found that the presence of clear cells, glycogen-containing cells, and trichilemmal keratinization were not exclusive to these tumors, as similar features were observed in Bowen's disease. However, immunohistochemical analysis revealed that trichilemmoma and mTr shared similar immunophenotypes with the ORS, particularly in the lower hair follicle, characterized by specific keratin and involucrin expression. This suggested that immunohistochemistry could be a valuable tool for accurately identifying and differentiating mTr, prompting a reevaluation of previous mTr diagnoses using these techniques.
