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Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Some treatments can stabilize Frontal Fibrosing Alopecia, but more research is needed to find effective treatments, and hair transplants often fail.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Certain drugs that block specific enzymes can help treat prostate diseases.

Starting 5-alpha reductase inhibitors does not significantly increase the risk of rhabdomyolysis in older men, but is linked to a higher risk of muscle conditions.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Finasteride can cause sexual dysfunction and depression, which may persist and require hormonal treatment.

Astragalus membranaceus helps regrow hair and reduce hair loss symptoms.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

The most effective treatments for hair loss are minoxidil, finasteride, PRP, and hair transplants, with steroids and immunosuppressants for autoimmune types.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Finasteride can treat hair loss, but may have side effects; evaluate and inform patients of risks.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.