Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study used a novel HPLC-radiomatic flow scintillation system to measure 5α-reductase activity in dermal papillae from miniaturized hair follicles of the human occipital scalp, revealing significant variability in enzyme activity across samples.

This study found that in men with high genetic risk factors for polycystic ovary syndrome, there was an associated increase in obesity, type 2 diabetes, coronary artery disease, and androgenic conditions, suggesting these genetic factors can act independently of ovarian function.

This study found that US adults with classic congenital adrenal hyperplasia most preferred a hypothetical adjunctive therapy that prevents glucocorticoid-induced weight gain over other potential benefits.

This study found that trichoscopic parameters in male androgenetic alopecia deteriorated progressively with increasing disease severity and were significantly linked to genetic, metabolic, and psychosocial factors.

In this commentary, the authors discuss emerging evidence primarily from pharmacovigilance data and retrospective studies indicating a potential association between GLP-1 receptor agonists, like semaglutide and tirzepatide, and hair loss, although causality remains unproven, prompting recommendations for patient monitoring and further research.

This review provides an educational resource on Polycystic Ovary Syndrome, detailing its pathophysiology and complications, and reports no new clinical results.

This infographic reviews the pathophysiology and complications of PCOS, illustrating how genetic and environmental factors contribute to its development, and highlights associated metabolic and neuroendocrine effects.

This study developed a bifunctional sodium hyaluronate microneedle patch incorporating glycyrrhizin-loaded dutasteride micelles and mesoporous polydopamine nanoparticles, which effectively inhibited DHT and reduced ROS in hair follicle cells, resulting in significantly accelerated hair growth in vitro and in vivo.

In this study, baricitinib improved the resolution of arthritis or rash in patients with systemic lupus erythematosus, but outcomes for skin involvement like alopecia were not reported.

This review discusses the complexities of hidradenitis suppurativa pathogenesis, highlighting issues with Notch signaling, immune dysregulation, and the role of keratinocytes and ECM, but reports no new clinical results.

People with hair loss have higher risk of high blood sugar and diabetes, and lower levels of a specific hormone.

This study found that untreated hirsute patients have lower expression of type 2 17β-HSD mRNA in scalp hairs, indicating potential disturbances in androgen metabolism, compared to treated hirsute patients.

This analysis explores possible causes of menstrual irregularities in women with PCOS following COVID-19, but reports no new clinical findings.

This review discusses PCOD's pathophysiology, clinical features, and management strategies but reports no new clinical findings, emphasizing the need for early diagnosis and multidisciplinary management.

The woman's rare combination of diseases suggests an unknown factor may predispose individuals to multiple endocrine diseases.

This case report presents a 14-year-old girl with type A insulin resistance, illustrating diagnostic processes to differentiate it from type 2 diabetes in the context of pediatric obesity and hyperglycemia.

In this study, herbal extracts commonly used in traditional medicine were observed to significantly increase the proliferation of human dermal papilla cells, suggesting potential as alternative therapies for enhancing hair growth.

This study found that IFN-γ plays a critical role in T cell activation and the pathogenesis of alopecia areata in C3H/HeJ mice.

In this study, researchers identified immune differences in children with alopecia areata, finding that cytokine profiles vary based on the presence of atopic diseases; notably, patients with atopy showed a heightened T helper 2 response, potentially influencing cytokine expression and disease severity.

This study observed increased proliferation and certain gene expressions in dermal papilla cells exposed to an 808 nm laser diode array at doses above 0.5 J/cm².

This review discusses how overlapping risk factors in women with polycystic ovary syndrome may heighten their risk for severe COVID-19, advocating for integrated care approaches but provides no new clinical results.

This study found that honokiol inhibits enzymes related to testosterone degradation in vitro, suggesting its potential as a lead compound for developing antiaging bioactive ingredients for men.

This review discusses the potential benefits and risks of selenium in cancer prevention and treatment, emphasizing that while selenium may offer advantages for tumor patients, further research is needed due to mixed findings regarding diabetes risk.

This review discusses the complexities in diagnosing polycystic ovary syndrome and emphasizes the need for individualized assessment based on each patient's specific symptoms and history, but reports no new results.

In this case report, the authors described a 46-year-old woman with severe atopic dermatitis and alopecia areata, who experienced significant improvements in both conditions after treatment with the interleukin-13 blocker tralokinumab, suggesting a potential therapeutic role for targeting type 2 cytokine IL-13 in such cases.

This study suggests that keratinocytes derived from hair follicles of patients with atopic dermatitis provide a useful model for investigating AD-related inflammation, as they showed greater expression changes of AD markers when stimulated with type 2 cytokines compared to those from healthy donors.

This study suggests that a mixture of Chrysanthemum zawadskii, peppermint, and Glycyrrhiza glabra promotes hair growth and reduces hair loss markers in testosterone-treated cells and mice.

This review discusses the current status of genetic research on male-pattern hair loss and reports no new findings, outlining significant achievements and future challenges in understanding its biology and treatment.

The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.

This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.