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UVB exposure in human skin causes macrophages to produce more IL-10 and less IL-12, leading to immunosuppression.

Targeting Vδ1+T-cells may help treat alopecia areata.

The MAGE3 hypothesis for alopecia areata did not lead to a significant breakthrough.

Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.

Higher CD70 and CD27 gene expression in alopecia areata lesions predicts disease severity and activity.

A substance called miR-1246 may help treat severe hair loss by reducing certain immune cell activities.

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

Genetic discoveries are leading to new treatments for alopecia areata.

Some skin conditions may increase the risk of heart disease, and understanding their connection could lead to better treatments.

Regulatory T cells help heal skin and grow hair, and their absence can lead to healing issues and hair loss.

COVID-19 can cause hair loss, and treatments like PRP and stem cells might help.

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

p14ARF and p16Ink4a cause hair follicle stem cell aging and dysfunction.

Hair follicles prevent NK cell attacks to avoid hair loss.

Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.

Different treatments for Hidradenitis suppurativa range from antibiotics and hormonal therapies to surgery, depending on severity.

Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

Macrophage iron release is crucial for hair growth and wound healing.

JAK inhibitors show promise in effectively treating hair loss from alopecia areata.

IL-3 worsens lupus nephritis and blocking it improves kidney health.

Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

TLR4 is important in aging-related diseases and could be a new treatment target.

DHT inhibition may increase spinal bone growth in ankylosing spondylitis.

Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.