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This study suggests that in an ex vivo rat glaucoma model, TSPO activation is involved in Allopregnanolone synthesis and may help prevent retinal damage, with TSPO agonists as potential therapeutic agents.

This study found that diazepam had an exaggerated effect on GABA-related inhibitory tone in diabetic neuropathic mice compared to normal mice, potentially due to mitochondrial dysfunction affecting neurosteroid synthesis.

This study found that the antidepressant-like effect of fluoxetine in mice was only observed when a 5-minute pretest session was conducted, and this effect was blocked by the TSPO antagonist PK11195.

This study observed that overexpressing TSPO in the hippocampal dentate gyrus of mice led to significant anxiolytic and antidepressant-like effects, potentially mediated by increased allopregnanolone synthesis.

The authors concluded that newly synthesized N-acyl-L-tryptophanyl-isoleucine amides showed high anxiolytic activity in animal models, comparable to diazepam, through interaction with the TSPO receptor.

In this study, overexpressing TSPO in the mouse hippocampal dentate gyrus led to significant anxiolytic and antidepressant-like effects, partly through increased allopregnanolone biosynthesis.

This study found that midazolam improved PTSD-associated behavioral deficits in rats through its action on the TSPO, CBR, and neurosteroidogenesis pathways.

This study found that midazolam, unlike clonazepam, increased neurosteroid levels and affected synaptic inhibition and plasticity in rat hippocampal neurons, suggesting unique actions via dual receptor activation.

This study suggests that paeoniflorin's protective effects on brain astrocytes may be mediated by TSPO and neurosteroids biosynthesis.

This study demonstrated that benzothiazepines, such as diltiazem and JTV-519, exert anxiolytic-like effects through allopregnanolone biosynthesis in mice, similar to carbamazepine.

AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.

This study found that estazolam improved PTSD-like behavior deficits in an animal model, which was linked to increased allopregnanolone levels in specific brain regions.

This study found that enhanced neurosteroid synthesis likely mediated by the translocator protein contributed to the anticonvulsant action of midazolam in mice.

This study found that the antiseizure activity of midazolam primarily occurs through synaptic GABA-A receptors, with no significant involvement of endogenous neurosteroids or extrasynaptic receptors.

This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.

This review summarizes the role of neurosteroids in seizure disorders and highlights the potential of neurosteroid replacement therapy in epilepsy but presents no new clinical findings.

This review discusses the presence of the StAR protein in 17 non-classical steroidogenic tissues, suggesting that advanced detection methods are needed for a complete understanding of its functions in these tissues.

This study found that progesterone significantly delayed epileptogenesis development in a mouse model, and its effects were inhibited by finasteride, highlighting the potential role of neurosteroids in modifying epilepsy progression.

This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.

This review discusses the role of δ-subunit-containing GABA A receptors and neurosteroids in temporal lobe epilepsy, highlighting their plasticity and potential pharmacological implications, without reporting new clinical results.

This review discusses the complexity of neuroactive steroid therapies for neuroprotection and reports no new clinical findings, suggesting potential unexpected effects in the brain compared to systemic levels.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

This study found that finasteride significantly improved motor, EEG, and cellular changes in a rat model of thioacetamide-induced hepatic encephalopathy and prevented the development of hepatic coma.

This study constructed a panel of pharmacokinetic and pharmacodynamic genes, revealing that current SNP chips insufficiently capture many drug-response gene variants, highlighting the need for complementary genetic approaches.

In this review, researchers detail how immunosenescence and chronic neuroinflammation contribute to Parkinson's disease progression, exploring potential therapeutic strategies targeting this axis, such as senolytic agents and immune rejuvenation, while highlighting associated challenges and future research needs.

This study found that neonatal administration of finasteride reduced sensitivity to alcohol's motor-stimulating effects and increased preference for novelty and initial alcohol consumption in rats, suggesting a role in alcohol vulnerability.

This article discusses the hypothalamus-pituitary-testis axis in androgen production and spermatogenesis but presents no new research findings.

This study found that AP-2α and AP-2β transcription factors are crucial for maintaining adult skin homeostasis, with their inactivation in keratinocytes leading to impaired differentiation, hair abnormalities, and inflammation, highlighting their key regulatory roles.

This chapter discusses charnolopharmacotherapeutics for various medical conditions and suggests antioxidant-loaded nanoparticles may improve treatment by enhancing central nervous system delivery and inducing charnolophagy.

This study suggests that cerebrospinal fluid levels of the neurosteroids allopregnanolone and pregnanolone correlate negatively with PTSD and negative mood symptoms, with potential sex-specific differences in synthesis enzyme blocks.