Role of Neurosteroids in the Anticonvulsant Activity of Midazolam
October 2011
in “
British Journal of Pharmacology
”
Research cited in this study
7 / 7 resultsresearch 11β-Hydroxylase Inhibitors Protect Against Seizures in Mice by Increasing Endogenous Neurosteroid Synthesis
research Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis
Midazolam impairs learning and memory by increasing neurosteroids through specific receptor activation.
research Involvement of Neurosteroids in the Anxiolytic-Like Effects of AC-5216 in Mice
research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride
Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
research A New Look at the 5α-Reductase Inhibitor Finasteride
Finasteride, a medication, is being re-evaluated for its effects and uses.
research Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAAReceptor Function and Seizure Susceptibility
The study provided evidence that stress-induced neurosteroids derived from deoxycorticosterone (DOC) modulated GABA(A) receptor function and affected seizure susceptibility. During stress, DOC was metabolized into neurosteroids like THDOC, which had anticonvulsant properties. In rats, acute stress increased THDOC levels and raised seizure thresholds. Similarly, small doses of DOC increased THDOC and seizure thresholds, effects reversed by finasteride, a 5alpha-reductase inhibitor. DOC also protected mice against various seizures, with its effects reversed by finasteride and partially by indomethacin. DHDOC, another metabolite, also potentiated GABA-activated currents, suggesting its role in DOC's antiseizure activity. Thus, DOC mediated stress effects on seizures through conversion to neurosteroids affecting GABA(A) receptors.
research Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice
Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.