January 2005 in “世界胃肠病学杂志:英文版(电子版)” This study found that etoposide enhances the radiosensitivity of CT26 colorectal adenocarcinoma in BALB/c mice, significantly inhibiting tumor growth without significant toxicity.
466 citations
,
June 2009 in “Experimental dermatology” This review discusses recent advances in understanding acne pathobiology, highlighting the potential for developing new customized therapies, but it reports no new clinical findings.
253 citations
,
March 2006 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses the hypothesis that polycystic ovary syndrome may originate in fetal life due to prenatal androgen exposure, but reports no new clinical results.
82 citations
,
September 2018 in “Nature Communications” This study found that stimulating the olfactory receptor OR2AT4 in human hair follicles with a synthetic sandalwood odorant promotes hair growth ex vivo by decreasing apoptosis and increasing IGF-1 production.
73 citations
,
October 2001 in “Epilepsia” In this study, valproic acid treatment was associated with reduced biotinidase activity and improved skin lesions after biotin supplementation in children with seizures.
70 citations
,
February 2018 in “Seminars in Arthritis and Rheumatism” This study found that belimumab helped achieve low disease activity in over 40% of systemic lupus erythematosus patients in real-life settings, alongside reduced corticosteroid use and fewer flares.
68 citations
,
January 2022 in “International Journal of Molecular Sciences” This review summarizes factors involved in polycystic ovary syndrome pathogenesis and management, highlights commonly prescribed and repurposed medications, and calls for well-designed clinical trials to evaluate these treatments further.
52 citations
,
October 2016 in “Clinics in Dermatology” This review discusses various drugs that can cause drug-induced acne, noting specific clinical and histopathologic features, but reports no new clinical findings.
30 citations
,
January 2023 in “EFSA journal” This review establishes a tolerable upper intake level of 255 μg/day for selenium in adults, warning that supplements and Brazil nuts may cause excess intake.
27 citations
,
June 2017 in “Expert opinion on investigational drugs” This review discusses ongoing and past trials for novel acne treatments, focusing on topical agents with potential sebosuppressive, antimicrobial, or anti-inflammatory effects, without reporting new clinical results.
24 citations
,
November 2016 in “Molecular Medicine Reports” This study found that women with acne resistant to conventional treatments had significantly higher levels of testosterone, DHEA‑S, prolactin, and LH, suggesting potential underlying hormonal disorders.
16 citations
,
March 2017 in “Journal of inclusion phenomena and macrocyclic chemistry” This study found that using 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD) to encapsulate minoxidil can create a stable aqueous solution, potentially replacing the need for organic solvents in topical treatments for androgenic alopecia.
16 citations
,
January 2008 in “Acta dermato-venereologica” Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.
13 citations
,
October 2019 in “Oncology Reports” This review discusses the complex relationship between anabolic substances and colorectal cancer risk, reporting ambiguous findings on their carcinogenic properties, potential synergy with risk factors, and protective roles.
12 citations
,
April 2023 in “Pharmaceutics” This review covers the current and potential medical uses of semifluorinated alkanes, including applications in eye surgery, drug delivery, and oxygen transport.
11 citations
,
August 2022 in “Journal of Investigative Dermatology”
9 citations
,
January 2001 in “Dermatology” This study reports two cases where pili anulati, typically a non-fragile hair condition, showed increased fragility due to androgenetic alopecia, causing hair shaft fracturing in the affected area.
6 citations
,
September 2017 in “Experimental and Therapeutic Medicine” This study found that two short peptides derived from pigment epithelium-derived factor significantly accelerated full-thickness skin wound healing in mice through mechanisms that may involve increased cell proliferation and stem cell mobilization.
6 citations
,
October 2015 in “Experimental dermatology” This study found that adenine supplementation in cultured human follicle dermal papilla cells stimulated proliferation and reduced senescence, possibly through AMPK activation and increased cellular NAD+ levels.
5 citations
,
February 2023 in “European journal of endocrinology” This study found that older patients with Cushing's syndrome had fewer typical symptoms of hypercortisolism, more comorbidities, and were more often treated conservatively compared to younger patients.
4 citations
,
December 1997 in “Clinical Endocrinology” This article presents a case of giant cell arteritis occurring in a patient with de Quervain's thyroiditis but reports no new clinical findings.
3 citations
,
May 2019 in “Medical Hypotheses” This article discusses the potential of using vitrified hair follicles from younger men with a family history of male pattern baldness to increase donor availability for future hair transplantation, and reports no clinical results.
3 citations
,
January 2016 in “US endocrinology” This study found no significant association between alopecia types and thyroid dysfunction, despite higher thyroid dysfunction rates in alopecia patients compared to the general U.S. population.
2 citations
,
December 2022 in “PNAS nexus” In laboratory experiments, this study found that the topical prodrug SCD-153, a derivative of 4-methyl itaconate, reduced inflammation-related gene expression and induced significant hair growth in mice, suggesting it as a promising treatment candidate for alopecia areata.
This study observed that in a real-world clinical setting in Greece, belimumab effectively controlled disease activity in lupus patients and allowed for a reduction in glucocorticoid dosage, with more pronounced benefits seen in patients who were serologically active at the start of treatment.
1 citations
,
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that fibroblast loss in the upper dermis from UVR exposure is linked to a deregulated inflammatory response, with T cells playing a protective role in fibroblast survival.
1 citations
,
March 2020 in “Poster presentations” This case report describes a female SLE patient with CNS involvement who developed an acute West Nile virus infection, highlighting the diagnostic challenges in differentiating infection from a disease flare in immunosuppressed individuals.
February 2026 in “Preprints.org” This review synthesizes the latest advances in wound healing and scar management, exploring molecular mechanisms, therapeutic strategies, and providing an evidence-based comparison of topical agents like Dermatix Ultra and Contractubex for scar improvement, aimed at informing clinicians and patients in decision-making.
February 2026 in “PubMed” This study reported that para-phenylenediamine and toluene-2,5-diamine are the main sensitizers in hair dye-related allergic contact dermatitis, with significant cross-reactivity to several other compounds.
May 2025 in “Drug Delivery and Translational Research”