Central Centrifugal Cicatricial Alopecia And Fibroproliferative Disorders: Exploring The Association With Uterine Leiomyomas

Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia predominantly affecting women of African descent, often linked to fibroproliferative disorders (FPDs) like uterine leiomyomas (ULs). A retrospective cohort study found that Black women with CCCA have nearly five times increased odds of having ULs compared to those without CCCA. The study also revealed that 80% of Black women with CCCA reported ULs, compared to 50% with lichen planopilaris (LPP). Upregulated fibroproliferative genes in CCCA-affected scalp areas suggest potential therapeutic targets, with antifibrotic agents like losartan and statins showing promise. Dermatologists are encouraged to screen for ULs and other FPDs in CCCA patients to improve diagnosis and quality of life.