Central Centrifugal Cicatricial Alopecia And Fibroproliferative Disorders: Exploring The Association With Uterine Leiomyomas

June 2024 in “ British Journal of Dermatology ”

Laksha Bala, Christie Tsang, Vani Agarwal, Noha Elshimy

Central centrifugal cicatricial alopecia CCCA fibroproliferative disorders FPDs uterine leiomyomas ULs lichen planopilaris LPP fibroproliferative genes antifibrotic agents losartan statins scarring alopecia fibroids

TLDR Black women with CCCA are more likely to have uterine fibroids.

Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia predominantly affecting women of African descent, often linked to fibroproliferative disorders (FPDs) like uterine leiomyomas (ULs). A retrospective cohort study found that Black women with CCCA have nearly five times increased odds of having ULs compared to those without CCCA. The study also revealed that 80% of Black women with CCCA reported ULs, compared to 50% with lichen planopilaris (LPP). Upregulated fibroproliferative genes in CCCA-affected scalp areas suggest potential therapeutic targets, with antifibrotic agents like losartan and statins showing promise. Dermatologists are encouraged to screen for ULs and other FPDs in CCCA patients to improve diagnosis and quality of life.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 90 upvotes 1 year ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community scarring alopecia awareness in this community

in Chat 33 upvotes 3 years ago

Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 6 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 2 years ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

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