Central Centrifugal Cicatricial Alopecia And Fibroproliferative Disorders: Exploring The Association With Uterine Leiomyomas

June 2024 in “ British Journal of Dermatology ”

Laksha Bala, Christie Tsang, Vani Agarwal, Noha Elshimy

Central centrifugal cicatricial alopecia CCCA fibroproliferative disorders FPDs uterine leiomyomas ULs lichen planopilaris LPP fibroproliferative genes antifibrotic agents losartan statins scarring alopecia fibroids

TLDR Black women with CCCA are more likely to have uterine fibroids.

Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia predominantly affecting women of African descent, often linked to fibroproliferative disorders (FPDs) like uterine leiomyomas (ULs). A retrospective cohort study found that Black women with CCCA have nearly five times increased odds of having ULs compared to those without CCCA. The study also revealed that 80% of Black women with CCCA reported ULs, compared to 50% with lichen planopilaris (LPP). Upregulated fibroproliferative genes in CCCA-affected scalp areas suggest potential therapeutic targets, with antifibrotic agents like losartan and statins showing promise. Dermatologists are encouraged to screen for ULs and other FPDs in CCCA patients to improve diagnosis and quality of life.

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community lost my hair in a single year of treatment at 20 years old

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community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

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