3 citations
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February 2019 in “Molecular genetics and metabolism” This study found that coadministration of tadalafil and finasteride improved lower urinary tract symptoms and erectile function in men with benign prostatic hyperplasia better than finasteride alone over 26 weeks.
January 2022 in “Drugs of Today” 52 citations
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January 2005 in “PubMed” This study concluded that alpha(1)-adrenoceptor antagonists are more effective than finasteride in the short term for reducing symptoms of lower urinary tract symptoms associated with benign prostatic hyperplasia.
April 2014 in “The FASEB Journal” This study suggests that testosterone may reduce knee joint range of motion by acting on relaxin receptors in rats, while flutamide and finasteride counteracted this effect and increased receptor expression.
October 2022 in “Journal of the ASEAN Federation of Endocrine Societies” This study found that GnRH-a treatment or orchiectomy, which required significantly lower doses of oral estradiol valerate, were more effective than anti-androgens like spironolactone and finasteride in achieving target hormone levels in transgender females in India.
11 citations
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August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that among the tested analogs, compound 4e was the most effective in inhibiting wax esters in vivo in the Golden Syrian hamster ear model.
April 2017 in “The Journal of Urology” This study found that patients with BPH who received finasteride before TURP experienced reduced intraoperative blood loss and improved quality of life one month after surgery compared to those who did not.
November 2011 in “国际泌尿系统杂志” This study concluded that intraprostatic injection with drugs and high frequency thermotherapy was more effective for treating prostatitis after TURP than a combination of antibiotherapy, tamsulosin, and finasteride.
1 citations
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March 2009 in “The Journal of Urology” This review discusses trials on therapies for benign prostatic hyperplasia and reports that combination treatment is more effective than monotherapy for symptom relief and slowing disease progression in men with moderate to severe symptoms and enlarged prostate glands.
5 citations
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March 2010 in “Gynecologic and obstetric investigation” This study found that parenteral administration of cyproterone acetate was more effective than high-dose oral treatment in reducing facial hair diameter and improving dermatological parameters in patients with severe hirsutism, despite similar androgen suppression.
3 citations
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October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals” This synthesis report details the successful development of a C-14 labeled isotopomer of LY300502, a 5α-reductase inhibitor, through a multi-step radiochemical process.
2 citations
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April 2007 in “Journal of Labelled Compounds and Radiopharmaceuticals” This article discusses the preparation of tritium-labeled testosterone metabolites and reports no new experimental findings.
This review concluded that 5α-reductase inhibitors like finasteride and dutasteride offer limited additional feminising effects in hormone therapy for transfeminine individuals, with the clearest use being androgenetic alopecia treatment; more research is needed for other potential benefits.
18 citations
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May 2014 in “Menopause” This study found that a 5-mg daily dose of transdermal testosterone cream in postmenopausal women restored testosterone levels to those typical of premenopausal women.
September 2018 in “Translational andrology and urology” This study explored the effects of MOTILIPERM on infertility in a rat model with varicocele and oxidative stress, reporting its potential therapeutic efficacy.
6 citations
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April 2009 in “Fertility and Sterility” Finasteride helps induce ovulation in nonresponder PCOS women.
17 citations
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August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.
November 2017 in “Reactions Weekly” Testosterone undecanoate caused hair loss; finasteride improved it but caused stomach issues for one patient.
January 2014 in “Side effects of drugs annual” This review discusses the 2011 publications on the side effects of sex hormones and related compounds, without reporting new clinical results.
10 citations
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April 1964 in “Journal of the American Geriatrics Society” This article reviews triamcinolone acetonide as an intramuscular long-acting steroid therapy for dermatologic disorders but reports no new clinical results.
1 citations
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September 2023 in “AACE clinical case reports” This case report describes two transgender men using subdermal testosterone pellets for gender affirmation, finding they tolerated the treatment, but one returned to injections; firm conclusions on pellets' suitability require further study.
June 2008 in “Drugs & therapy perspectives” Dutasteride effectively treats benign prostatic hyperplasia, improving symptoms and quality of life.
3 citations
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May 2017 in “Bioorganic & medicinal chemistry letters” This study identified compounds 11d and 11k as potential dual 5α-reductase inhibitors and AR antagonists with significant anti-proliferative effects on prostate cancer cell lines, suggesting they may offer therapeutic value.
15 citations
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June 1961 in “Archives of Dermatology” This report details observations from four patients with alopecia areata who received intralesional triamcinolone injections to assess its effectiveness for promoting hair regrowth in localized areas.
September 2018 in “The Journal of Urology” This study found that both Clomiphene Citrate and Human Chorionic Gonadotropin were effective in restoring testosterone levels in men with hypogonadism, as demonstrated in a short-course randomized study.
64 citations
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January 1985 in “Clinical endocrinology” In this study, treatment with the oral contraceptive containing 30 μg ethinyl oestradiol and 150 μg desogestrel significantly reduced androgen-dependent hair growth in hirsute women over one year.
14 citations
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May 2005 in “Steroids” This study describes the synthesis of finasteride from 4-androstene-3,17-dione in a seven-step process with an overall yield of 18.6%.
March 2024 in “The journal of sexual medicine” This case study observed that in four middle-aged men with ejaculation disorders, therapy with human chorionic gonadotropin (hCG) alone or combined with recombinant follicle-stimulating hormone (rFSH) improved sexual desire, semen volume, and various other symptoms, although some experienced elevated estradiol levels and hair loss.
6 citations
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July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review evaluates the use of 5α-reductase inhibitors in feminising hormone therapy, finding their additive feminising benefits unclear due to their specific action on testosterone conversion, with concerns highlighted regarding limited supporting evidence and safety signals, particularly for psychiatric and sexual effects.
4 citations
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March 2018 in “Journal of labelled compounds & radiopharmaceuticals” In this study, researchers developed a new prostate cancer imaging agent, a [99m Tc]tricarbonyl complex derived from finasteride, which demonstrated high radiochemical purity and significant uptake in the prostate of a rat model, suggesting its potential for noninvasive prostate cancer imaging.