Two Transgender Men Receiving Subdermal Testosterone Pellets for Gender Affirmation

    September 2023 in “ AACE clinical case reports ”
    Sune L. Wolf Pulsiano, Jenna Sarvaideo
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    TLDR Testosterone pellets might work for transgender men's hormone therapy, but more research is needed.
    The document reports on two cases of transgender men using subdermal testosterone pellets for gender affirmation. Patient 1, a 47-year-old, experienced wide fluctuations in testosterone levels with pellets and returned to injections. Patient 2, a 20-year-old, found pellets to be a suitable alternative after struggling with gel and injections. Both patients tolerated the pellets well without significant adverse effects. The study suggests that testosterone pellets could be a viable long-acting option but stresses the need for larger, controlled studies to determine optimal dosing and to monitor for risks like erythrocytosis.
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