Effect of Testosterone and Its Antagonists on Knee Range of Motion Through RXFP1 and RXFP2 Regulation in Rat Model

April 2014 in “ The FASEB Journal ”

Firouzeh Dehghan, Sekaran Muniandy, Ashril Yusof, Naguib Salleh

testosterone flutamide finasteride RXFP1 RXFP2 Propecia

TLDR Testosterone reduces knee movement, while flutamide and finasteride increase it.

The study investigated the effects of testosterone and its antagonists, flutamide and finasteride, on knee joint range of motion (ROM) and relaxin receptors in ovariectomized female Wistar Kyoto rats. It involved 42 rats divided into seven groups, with treatments administered over three days. Results indicated that testosterone reduced knee ROM, while flutamide and finasteride increased it by blocking testosterone's effects. Both antagonists similarly affected RXFP1 and RXFP2 receptor expression in the patellar tendon and collateral ligament, suggesting that testosterone was a primary mediator in reducing knee ROM through these receptors. The study was supported by a PPP grant.

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