April 2014 in “The FASEB Journal” This study suggests that testosterone may reduce knee joint range of motion by acting on relaxin receptors in rats, while flutamide and finasteride counteracted this effect and increased receptor expression.
23 citations
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March 2014 in “International Journal of Molecular Sciences” The study observed that testosterone reduced knee range of motion in ovariectomized female rats, potentially by downregulating specific relaxin receptor isoforms, with its effects mediated via dihydro-testosterone.
This study found that in both rodents and humans, knee laxity increased at certain phases of the reproductive cycle due to sex-steroid influence, particularly under high levels of estrogen and progesterone.
60 citations
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January 2021 in “BMC Genomics” This study mapped genomic copy number variation in Chinese fine-wool sheep, identifying genes involved in sensory perception, nutrient metabolism, growth, and development, and highlighting significant selection on the RXFP2 gene.
January 2021 in “Research Square (Research Square)” This study mapped copy number variations in Chinese fine-wool sheep, identifying regions linked to important traits like milk production and growth, and highlighting a strong selection signal at the RXFP2 gene.