research Effect of Testosterone and Its Antagonists on Knee Range of Motion Through RXFP1 and RXFP2 Regulation in Rat Model
Testosterone reduces knee movement, while flutamide and finasteride increase it.
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5 / 16 resultsresearch Testosterone Reduces Knee Passive Range of Motion and Expression of Relaxin Receptor Isoforms via 5α-Dihydrotestosterone and Androgen Receptor Binding
Testosterone reduces knee flexibility by affecting relaxin receptors.
research The Effects of Sex Steroids and Menstrual Cycle/Oestrous Phases on Knee Ligament Laxity in Humans and Rodents
The study investigated the effects of sex-steroids and menstrual cycle phases on knee ligament laxity in both rodents and humans. In rodents, ovariectomized rats treated with oestrogen and progesterone showed increased knee range of motion (ROM), while testosterone decreased it. This was linked to the up-regulation of relaxin receptor isoforms RXFP1 and RXFP2, which were antagonized by steroid hormone receptor blockers. In humans, female athletes and non-athletes exhibited significant differences in knee laxity across menstrual cycle phases, with the highest laxity during ovulatory and menstrual phases. Non-athletes had greater knee laxity compared to athletes. The study highlighted a strong correlation between knee laxity and serum relaxin levels, providing insights into the mechanisms of sex-steroid control of knee ROM and the increased susceptibility of females to non-traumatic knee injuries during certain reproductive phases.
research Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology
Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.
research New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men
The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.
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