A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing

    January 2021 in “ BMC Genomics ”
    Chao Yuan, Zengkui Lu, Tingting Guo, Yaojing Yue, Xijun Wang, Tianxiang Wang, Yajun Zhang, Fujun Hou, Chune Niu, Xiaopin Sun, Hongchang Zhao, Shaohua Zhu, Jianbin Liu, Bohui Yang
    TLDR The study mapped genetic variations in sheep, linking them to traits like milk production and growth.
    The study conducted a genome-wide analysis of copy number variations (CNVs) in 32 Chinese indigenous fine-wool sheep using whole-genome resequencing, identifying 1,747,604 CNVs and 7,228 CNV regions (CNVRs) covering 2.17% of the sheep reference genome. These CNVRs were associated with sensory perception, nutrient metabolism, and growth processes, and 1,855 CNVRs were linked to 166 quantitative trait loci (QTLs) related to milk production, carcass traits, and health. The study highlighted the RXFP2 gene under strong selection pressure in horned versus polled sheep and provided a comprehensive CNV map, enhancing the understanding of genetic variation and complex traits in sheep.
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