Testosterone Reduces Knee Passive Range of Motion and Expression of Relaxin Receptor Isoforms via 5α-Dihydrotestosterone and Androgen Receptor Binding

March 2014 in “ International Journal of Molecular Sciences ”

Firouzeh Dehghan, Sekaran Muniandy, Ashril Yusof, Naguib Salleh

testosterone 5α-dihydrotestosterone androgen receptor flutamide 5α-reductase inhibitor finasteride relaxin receptor Rxfp1 Rxfp2 DHT androgen receptor blocker Propecia

TLDR Testosterone reduces knee flexibility by affecting relaxin receptors.

The study investigated the effects of testosterone on knee passive range of motion (ROM) and relaxin receptor expression in ovariectomized female Wistar rats. Testosterone at doses of 125 and 250 μg/kg significantly reduced knee ROM and decreased the expression of relaxin receptor isoforms Rxfp1 and Rxfp2 in the patellar tendon and lateral collateral ligament. These effects were mediated by 5α-dihydrotestosterone (DHT) and androgen receptor binding, and could be antagonized by flutamide and finasteride. The study involved 6 rats per treatment group and suggested that testosterone decreased knee laxity by downregulating relaxin receptor expression, with DHT playing a key role. However, caution was advised when extrapolating these findings to humans due to species differences.

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