A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing
January 2021
in “
Research Square (Research Square)
”
Studysummary This study mapped copy number variations in Chinese fine-wool sheep, identifying regions linked to important traits like milk production and growth, and highlighting a strong selection signal at the RXFP2 gene.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study analyzed the genome-wide distribution of copy number variations (CNVs) in 32 Chinese indigenous fine-wool sheep from three breeds using whole-genome resequencing. A total of 1,747,604 CNVs were detected, resulting in 7,228 CNV regions (CNVRs) that covered 2.17% of the sheep reference genome. Deletion events were more common than duplication events. The CNVRs were associated with genes involved in sensory perception, nutrient metabolism, and growth processes, and 1,855 CNVRs were linked to 166 quantitative trait loci (QTLs) related to milk, carcass, and health traits. The study also identified the relaxin family peptide receptor 2 (RXFP2) gene as being under strong selection pressure in horned and polled sheep groups. This research provided a valuable genetic variation resource for further sheep genome studies.
