A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing

    January 2021 in “ Research Square (Research Square) ”
    Chao Yuan, Zengkui Lu, Tingting Guo, Yaojing Yue, Xijun Wang, Tianxiang Wang, Yajun Zhang, Fujun Hou, Chune Niu, Xiaopin Sun, Hongchang Zhao, Shaohua Zhu, Jianbin Liu, Bohui Yang
    TLDR Chinese fine-wool sheep have genetic variations linked to traits like milk and health, with some genes under strong selection.
    This study analyzed the genome-wide distribution of copy number variations (CNVs) in 32 Chinese indigenous fine-wool sheep from three breeds using whole-genome resequencing. A total of 1,747,604 CNVs were detected, resulting in 7,228 CNV regions (CNVRs) that covered 2.17% of the sheep reference genome. Deletion events were more common than duplication events. The CNVRs were associated with genes involved in sensory perception, nutrient metabolism, and growth processes, and 1,855 CNVRs were linked to 166 quantitative trait loci (QTLs) related to milk, carcass, and health traits. The study also identified the relaxin family peptide receptor 2 (RXFP2) gene as being under strong selection pressure in horned and polled sheep groups. This research provided a valuable genetic variation resource for further sheep genome studies.
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