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This paper reviews the current lack of evidence on the safety and effectiveness of gender-affirming therapies in minors with gender dysphoria, highlighting ethical and legal concerns, including possible long-term consequences such as infertility.

This study found that while iron depletion through phlebotomies is safe for women with functional ovarian hyperandrogenism, it does not improve their cardio-metabolic profile and may reduce non-enzymatic antioxidant capacity.

This study developed a new analytical method to identify a wide range of endocrine disrupting compounds in full-term amniotic fluid, revealing diverse substances with potential endocrine activity.

In this study, facial hypertrichosis occurred in 10% of women treated with isotretinoin for acne, but it resolved spontaneously after the treatment ended.

This source outlines the potential effects of treatments commonly used in trichology on SARS-CoV-2 infection and offers a guide for managing trichological patients during the COVID-19 era, addressing the challenges of safely visiting and treating patients.

This study found that twice-daily application of 5% Minoxidil did not significantly impact hair growth in Sinclair minipigs over 27 days.

This article discusses the assumptions linking sex, gender identity, gender role, and sexual orientation, highlighting that these inferences are often incorrect, but it reports no new empirical results.

This study suggests that unliganded vitamin D receptors in mice may cause more severe skeletal and mineral ion defects than VDR-null conditions, and vitamin D analogues may restore function in specific VDR mutations.

This review discusses the role of various hormones in diffuse hair loss and emphasizes the need for further research to clarify their complex interactions and potential therapeutic implications, but reports no new clinical results.

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

This review discusses various psychiatric treatments including antipsychotics, insomnia medication, and mood stabilizers, but reports no new clinical results; the authors comment on existing findings and approvals.

This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.

This review examines complex regional pain syndrome (CRPS I) mechanisms, including immune dysregulation and psychological factors, but reports no new clinical results; the authors highlight potential diagnostic refinements.

This study suggests that weekly oral finasteride may be a promising alternative to isotretinoin for treating nodulocystic acne, showing substantial improvements with lower incidence of sexual dysfunction.

The researchers reported that during early embryogenesis and larval development in Silurana tropicalis, inhibiting steroidogenic enzymes cyp19 and srd5beta affects genes related to thyroid and reproductive systems.

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

This article reviews the potential advantages of secretome derivatives from human uterine cervical stem cells in MSC therapy and notes the need for regulatory standards to ensure safety and efficacy.

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

This study identified new dietary ligands for the human vitamin D receptor, including curcumin and gamma-tocotrienol, which may influence its biological functions.

The authors updated recommendations on diagnosing and treating women's sexual dysfunctions, emphasizing a comprehensive assessment approach, while noting the need for further multidisciplinary research.

This review discusses the classification and diagnosis of pregnancy-related skin conditions and reports no new clinical findings.

This review explores the role of TGF-β superfamily pathways in stem cell environments and their implications for tissue regeneration and cancer development, reporting no new experimental results.

This article reviews the complex pathophysiology of polycystic ovary syndrome, highlighting how genetic, hormonal, and environmental factors contribute to its diverse symptoms, and reports no new results.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

The researchers reported that dsRNA from damaged skin activates TLR3, promoting hair follicle regeneration, while TLR3-deficient animals fail to initiate this process, suggesting potential therapeutic approaches for hair neogenesis.

This review discusses the functions and potential therapeutic targeting of TRP ion channels in the skin, noting their involvement in both physiological processes and various pathological conditions, but reports no new experimental results.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

In this study, a novel mutation in the glucocorticoid receptor gene was identified in a young woman, impairing glucocorticoid signaling and leading to generalized glucocorticoid resistance.

This study found that the progestins norgestimate and dienogest may help treat clinical hyperandrogeny in women by inhibiting skin 5 alpha-reductase activity with minimal androgenic potential.