Complex Regional Pain Syndrome Type I: Measurements and Treatment

The document explored Complex Regional Pain Syndrome Type I (CRPS I), examining its immunological, neuropathic, and psychological mechanisms, as well as clinical presentation and treatment options. It found a link between HLA expression and poor treatment outcomes, and identified increased neuropeptide release as a neuropathic mechanism causing symptoms like increased skin temperature and edema. CRPS I patients experienced higher emotional distress, and the condition was marked by pain, sensory deficits, autonomic symptoms, and motor dysfunction. The International Association for the Study of Pain (IASP) provided diagnostic criteria, but modifications were suggested for research. Treatment options included physical therapy, psychotherapy, and pharmacological interventions, though their effectiveness needed further study. The document emphasized the complexity of CRPS I and the necessity for comprehensive management strategies.